Research Associate, cell line development and protein expression

Research Associate, cell line development and protein expression

Newark, CA /

Upstream Process Development /

Full-time

/ On-site

At Alector, our mission is to develop therapies that empower the immune system to combat neurodegeneration and cancer . Our team is solely focused on developing treatments for some of the most challenging diseases facing our society. We are supported in this mission by experienced and accomplished scientists and clinicians, leading healthcare investors, and pharma company partners who share in our commitment to bettering the lives of patients.

Key responsibilities for this role include supporting the production of recombinant protein and/or antibody expression in mammalian host systems in benchtop scale and bioreactors. You will support cell culture process scale-up to support early and late-stage projects.

During your first year, your goals will include:

• Maintain mammalian cell culture in static and shake cultures and all tasks related to mammalian cell culture which will include preparing media and feeds
• Transient production of recombinant proteins and antibodies, including planning, transfection, harvest, and titer assays.
• Stable cell line development from transfection to clone stability.
• Perform high throughput cloning and screening of clones
• Develop an experimental plan and be able to execute cell culture studies in the laboratory
• Perform routine laboratory operations such as seed culture expansion in shake flasks and bioreactors, production cultures in shake flasks, wave bag, and single-use bioreactors, product harvest, routine in-process analytical testing, etc.
• Support process optimization and process characterization work to develop scalable and manufacturing-friendly processes
• Experience with ambr systems preferred

We'd love to hear from you if you have:

• BS in Biology, Biochemistry, or Chemical/Biochemical engineering or in a related life-sciences field
• Minimum 3 years of experience in cell culture/fermentation process development and/or manufacturing sciences supporting cell culture operation in the biopharmaceutical/biotechnology industry.
• Minimum 1 year of hands-on experience in process scale-up or operation of large-scale bioreactors and cell culture equipment.
• Excellent aseptic technique is a must
• Team player, with no task too small attitude
• Willingness to learn

#LI-CH3

#LI-Onsite

Alector is a phenomenal place to learn and grow. Alector is a dynamic environment where teams are encouraged to experiment, take ownership of decisions, and question convention to solve complex problems. At Alector, we value shared wins, perseverance, and a growth mindset.

Alector was named on Fortune's " Best Workplaces in Biopharma " top list for small and medium-sized companies for the second year! And we moved up from #16 to #11 in 2022 .

Among the things you'll discover at Alector on Day 1 and throughout your tenure: Committed and driven colleagues, a bold and important company goal, brand-new brightly lit offices in Oyster Point, right at the heart of Biotech Bay. Alector offers flexible remote work options, and competitive compensation and benefits. Come join us!

At Alector, we believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other's assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws.

Employees of Alector working on-site are required to be vaccinated against COVID-19, and are required to provide proof of vaccination. Employees may be entitled to an exception or reasonable accommodation if they cannot be vaccinated because of a disability/medical necessity, or sincerely held religious belief.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation.