Post-Doctoral Research Fellow, more...
Location:Seattle, WA
Company:Fred Hutch
First posted:June 12, 2018 (last updated 30+ days ago)


Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch's pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation's first and largest cancer prevention research program, as well as the clinical coordinating center of the Women's Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


The Kublin Lab within the Vaccine and Infectious Disease Research Division is recruiting a postdoctoral fellow to work on a project investigating the role of the microbiome in vaccine-induced immunity. We are interested in how the gut microbial and immune systems communicate to shape immune responses to HIV vaccines and contribute to vaccine response heterogeneity. We will unravel mechanisms of immunity by perturbation of the immune system and the microbiome - the immune system via multiple adjuvanted immunization regimens in humans and murine models and the microbiome by gut microbial reconstitution in germ free murine models. Novel computational analyses integrating immune response, microbial relative abundance and metabolomics data will help guide vaccine and adjuvant design.

The candidate must be responsible, organized, and self-motivated, and able to efficiently manage time and experiments. The incumbent will help develop and apply the analytical tools necessary for interpreting the extensive clinical and murine microbiome and immunogenicity data, under the mentorship of the PI and computational biology faculty.


  • PhD in computational biology, biostatistics, molecular biology, immunology, microbiology or a related field.
  • Preference will be given to candidates with extensive experience in computational biology and bioinformatics, with a background in microbiology and/or immunology.
  • The candidate must show initiative, willingness to learn new skills and take up new responsibilities, and must be a team player.
  • Expertise in metagenomic shotgun sequencing, 16S rRNA gene amplicon sequencing, genome-scale metabolic modeling, comparative genomics, phylogenetics, and/or transcriptomics desirable.
  • Experience with bioinformatic and data science toolkits in Python, R, and/or bash is desirable.
  • Ability to work both independently and as part of a laboratory team
  • Excellent attention to details and scientific rigor
  • The successful candidate will be a highly motivated individual, with exceptional communication and organizational skills and an excitement for learning.

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