Vertex Summer 2025 Intern, DMPK (Boston, MA)

Job Description

The Vertex Internship Program offers students the opportunity to learn about the pharmaceutical industry from a hands-on perspective. You will be working closely with and learning from some of the brightest people in the industry. When you join our internship program you should not be surprised to see that our environment is one that is innovative and team oriented, where collaboration is not just a word, and "we are relentless" is in everything we do. Students can expect to be challenged by their project plan, connect with other interns,and feel valued by the Vertex community. Not only will interns learn about their day-to-day tasks through their specific work assignments, but they will interact and have exposure to our organizational leaders and their teams.

Job Summary:

We are seeking a summer intern to establish preclinical PBPK models that can be utilized in the progression of pipeline compounds to support clinical candidate nomination based upon historical knowledge. The intern will work closely with the preclinical modeling and simulation team, which will drive innovation, to establish PBPK workflows for FIH dose prediction

Key Responsibilities:

• Under the guidance of a mentor, the research intern will be involved in compiling preclinical data, developing PBPK models, and predicting human PK profiles using translational approaches. The intern will develop and apply relationships across ECCS classifications, including IVIVE to better inform how preclinical PBPK models can be predictive of human PK based on historical data
• Development of PBPK compound files in Simcyp
• Summarize findings in posters for presentation internally

Qualifications:

• Graduate student (MS or PhD) in Pharmacometrics, Pharmacokinetics, Pharmaceutical Sciences, Pharmacometrics, Applied Mathematics, or related disciplines.
• The candidate will be proficient in PBPK modeling concepts.
• Experience with data visualization
• The candidate should be proficient in Simcyp, GastroPlus, and Phoenix WinNonLin.
• Proficiency in programming language such as R, Python, or Matlab is a plus
• Permanent legal authorization to work in the United States
• Candidate must be enrolled in an advanced degree program if graduating before May 2025
• Candidate must be available to work full-time, 40 hours per week from May - August 2025

Program Dates: May - August 2025, Full Time

This job posting is for a temporary role with a third-party agency partner that provides services to Vertex. The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com