Research Specialist II - Pagliarini Lab

The Howard Hughes Medical Institute (HHMI) advances the discovery and sharing of scientific knowledge to benefit us all. As a biomedical research organization and philanthropy, HHMI supports a vibrant community of academic researchers, educators, students, and professionals. Together, we're unlocking the fundamentals of biology and building an open, inclusive future for science.

The Pagliarini Lab located at the Washington University in St. Louis is seeking a talented and motivated member to join the team as a Research Specialist II. In particular, they seek an experienced scientist with interest in establishing small molecule screening and/or genetic assay systems for exploring new mitochondrial biology and therapeutics. The Lab of Dr. Dave Pagliarini consists of an interdisciplinary team of scientists driven to understand the biochemical underpinnings of mitochondrial dysfunction in human diseases. Together, they integrate large-scale methodologies with traditional biochemistry to investigate the modulation, adaptation, and basic metabolic function of mitochondria. More information about the lab and their work can be found by visiting https://pagliarinilab.org/.

What We Provide:

• A competitive compensation package with comprehensive health and welfare benefits.

• Opportunity to work with a large team of experts in mitochondrial biology and biochemistry to build assay systems as a basis for exploring potential therapeutics and/or tools.

• Being part of a diverse and vibrant community. The Pagliarini Lab consists of a diverse group of scientists with backgrounds including organic chemistry, mechanistic biochemistry, cell & molecular biology, genetics, neuroscience, medicine & physiology, mass spectrometry, and computational biology.

What You'll Do:

• Design and perform high-level experiments, master literature, and engage with lab team members to learn the background of projects.

• Prepare reports, meet with others at Washington University to access resources, write manuscripts or grant applications.

• Operate and help maintain common lab equipment.

• Train others in complex technical protocols.

• Conduct literature reviews to determine suitable research methods.

What You Bring:

• PhD degree in biochemistry, chemical biology, molecular biology, cell biology; or an equivalent combination of education and related work experience.

• Experience as a Postdoctoral Fellow is preferable but not required.

• Experience in small molecule screens and cellular reporter assay/design is preferable.

• Familiarity with yeast and mammalian cell systems is preferable.

• Excellent written and verbal communication skills.

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances or other hazardous materials.

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

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Please Note:

This job description sets forth the job's principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word "may," the Essential Duties and Responsibilities described above are "essential functions" of the job, as defined by the Americans with Disabilities Act.