Lead Researcher / Scientist - Mefford Lab

The Mefford Lab is seeking a Lead Researcher/Scientist to join our dynamic Neurogenetics team in the Center for Pediatric Neurological Disease Research (CPNDR). CPNDR is part of the St. Jude Pediatric Translational Neuroscience Initiative, which aims to integrate basic, translational and clinical research to better understand and treat rare pediatric neurogenetic conditions. The Mefford lab research performs bench-to-bedside research focusing on genetic epilepsies and neurodevelopmental disorders. In this position, the candidate will collaborate on or lead projects to create and characterize patient-derived or engineered stem cell models, including 2D and 3D neuronal lines for disease characterization and treatment using precision therapy approaches. Depending on experience and interest, the candidate will participate in a range of projects in the lab employing state-of-the-art genomic, epigenetic, disease modeling and precision medicine approaches.

Qualified candidates will be proficient with primary and stem cell culture, iPSC and/or organoid propagation, and a wide spectrum of molecular, biochemical, and cellular assays. A strong background in molecular and cellular biology, developmental and stem cell biology, and neuroscience is required; experience with single-cell RNA-seq is preferred. A strong background in genetics or functional genomics and some experience with analysis of large datasets is preferred. Excellent written and communication skills, the ability to effectively collaborate with fellow trainees and scientists, and the ability to execute tasks in a timely manner are highly desired. The candidate should have a proven record of driving a project to completion.

Job Responsibilities:

• Conduct experiments and projects independently under overall direction of the PI
• Establish and characterize models of neurogenetic diseases using fibroblast, iPSC, 2D neurons and 3D organoid lines
• Develop and implement new research protocols, techniques, and procedures
• Collaborate with other lab members, departmental cores, and St. Jude investigators to accomplish broader goals
• Clearly communicate with internal and external stakeholders (including international collaborators and patient advocacy groups). Present results across various internal and external forums.
• Contribute to or lead the drafting and editing of manuscripts, posters and grants
• Maintain up-to-date knowledge of the field and related techniques
• Train incoming researchers or trainees as needed
• Perform other related duties to meet the goals of the department and institution.

Minimum Education and/or Training:

• Bachelor's degree in relevant scientific area is required

Minimum Experience - Lead Researcher

• Bachelor's degree plus 5 years of post-degree experience
• Master's degree plus 2 years of post-degree experience
• PhD with or without post-degree experience

Minimum Experience - Scientist

• Bachelor's degree plus 7 years of post-degree experience
• Master's degree plus 5 years of post-degree experience
• PhD with 3 years post-degree experience

Compensation

Explore our exceptional benefits!

Diversity, Equity and Inclusion

St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment.

Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.

No Search Firms

St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.