Scientist, In Vitro Pharmacology

Neurocrine Biosciences
United States, California, San Diego
Nov 21, 2024
Who We Are: At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options. What We Do: Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, endometriosis* and uterine fibroids, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visitneurocrine.com, and follow the company on LinkedIn, X (Formerly Twitter) and Facebook. (in collaboration with AbbVie) About the Role: Our dynamic team is seeking a scientist with demonstrated experience in designing, troubleshooting and executing SPR and/or BLI studies to support our early antibody, peptide and small molecule discovery programs. A successful candidate will have a record of independently and successfully interrogating, through label-free methods, binding affinities, off-rates, pH dependent interactions, dual-engagement binding, competition, and epitope binning, using various antigen formats that include Nanodisc and VLP. Experience measuring binding kinetics on cells is a plus. The successful individual will work in a cross-functional setting to design, develop and execute assays to deliver robust and high-quality decision-making data. This laboratory position requires exceptional scientific, technical and laboratory skills, strong organizational and communications skills, and enthusiasm in contributing to a fast-paced organization focused on discoveries of novel and differentiated therapeutic candidates. _ Your Contributions (include, but not limited to): Design, execute, and analyze SPR and BLI experiments to determine antibody affinity (KD), kinetics, pH dependent binding, competition experiments, dual-target engagement, epitope binning against various antigens, including recombinant proteins, Nanodisc, VLP. Experience with cells a plus Independently develop, optimize and troubleshoot protocols to evaluate monospecific and bispecific antibodies, scFv, Fabs, peptides and small molecules Apply extensive QC parameters to data to identify and troubleshoot issues Extensive knowledge of Biacore Insight and Octet Analysis software for data analysis Regular maintenance of SPR and BLI instrumentation Prepare high-quality data reports and presentations for project meetings Collaborate with scientists in a highly matrixed environment across multiple therapeutic areas and function teams Stay current with the latest advancements in SPR, BLI, and antibody, peptide and small molecule characterization techniques Must be highly organized with strong attention to details, and an eye on critical decision-making data generation Requirements: BS/BA degree in scientific field and 2+ years of in vitro pharmacology experience; Preferred experience includes: SPR and BLI for characterizing protein-protein interactions and binding kinetics, related assay development and troubleshooting OR MS/MA degree in scientific field and some relevant industry experience OR PhD in biology or related field preferred and some experience with antibody drug discovery, antibody characterizations, assay development and optimization and related troubleshooting, experience with SPR and BLI is required. Preferred experience includes: SPR and BLI for characterizing antibody-protein interactions with strong assay development and troubleshooting skills Recognizes fundamental anomalies in data points and identifies issues in experiments / processes Begins to understand how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals Strong knowledge of one scientific discipline Good knowledge of scientific principles, methods and techniques Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools Ability to work as part of a team Strong computer skills Good communications, problem-solving, analytical thinking skills Detail oriented Ability to meet deadlines Good project management skills Demonstrated experience with measuring antibody binding kinetics, pH dependent, competition binding, dual engagement binding studies using Biacore SPR methods Experience with obtaining epitope binning and binding/competition binding studies using Octet BLI methods Ability to QC and troubleshoot experiments. Collaborative and highly motivated #LI-DM1 Neurocrine Biosciences is an EEO/AA/Disability/Vets employer. We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description. _ The annual base salary we reasonably expect to pay is $86,200.00-$125,050.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.