Proteomics Scientist of Disease, Signaling and Complex Biological Systems

The Proteomics Group (Steven Carr Lab) at the Broad Institute of MIT and Harvard is looking for highly motivated scientist to develop and apply state-of-the art mass spectrometry-based proteomics technology to address compelling questions in biology, chemistry and clinical medicine. The specific research areas of immediate interest that this scientist could drive include:

• proteogenomic studies of a wide range of cancers;
• detailed studies of cellular signaling networks related to protein phosphorylation, ubiquitylation or acetylation;
• chemical proteomics technologies such as thermal profiling, affinity purification MS etc. that could be used for unveiling the drug targets or identifying protein interactorstargets of drugs;
• developing biological understanding of response and resistance to therapy;
• developing and optimizing new, broadly enabling proteomic technologies including targeted, quantitative MS assay development for proteins and modifications of high biological or clinical interest.

Successful candidates will work in one or more of these areas together with an interdisciplinary team of clinicians, biologists, computational and proteomics scientists to deeply characterize and understand the proteomes of tumor-derived material, cells and biofluids.

The Broad Institute is a world-leading non-profit research organization dedicated to realizing the promise of the post-genomic era for human benefit. Located in Cambridge, MA with strong ties to MIT, Harvard, and world class Boston hospitals, the Broad Institute brings together scientists of diverse backgrounds to solve critical problems in biology and medicine in an interdisciplinary manner. The Broad Institute, and the embedded Proteomics Group, have an outstanding track-record in training the next generation of research scientists. We (www.broadinstitute.org/proteomics) have a very strong track record in developing and applying proteomic technologies critical to address important questions in biology and medicine. We collaborate with top-level international researchers throughout the world, and results of these studies and our technology developments are published in top-tier journals.

Qualifications
Candidates must have:

• an MD or Ph.D. in areas such as analytical chemistry, molecular biologybiology, biochemistry, computational biology or preferably interdisciplinary sciences merging laboratory and bioinformatic skill set. a closely related field
• excellent scientific productivity, evidenced by high-quality research publications in peer reviewed journals
• track record of conducting independent and creative research
• analytical aptitude for devising innovative scientific or technical solutions
• excellent verbal and written communication skills

Hands on skills and knowledge in one or more of the following areas would be considered an advantage:

• state-of-the-art mass spectrometry- based proteomics
• expertise in statistical and/or computational analysis of large-scale proteomic or genomic data
• analysis of cell signaling pathways/networks
• cell biology/ biochemical methods to understand protein function
• Molecular and cell biology techniques. Knowledge of gene manipulation technologies such as CRISPR is desirable, although is not a requirement biochemical and molecular biology/CRISPR-based genome editing