Research Technician-Orthopedic Translational Research

SHIFT:

Seeking Breakthrough Makers

Children's Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care-and your career.

CHOP's Commitment to Diversity, Equity, and Inclusion

CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.

We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.

A Brief Overview

Research in Dr. Maurizio Pacifici's lab focuses on the cellular and molecular mechanisms that regulate skeletal growth and morphogenesis in fetal and postnatal life, using mammalian animal models as experimental tools. The information derived from these basic science research projects is used to uncover and understand the pathogenesis of congenital pediatric musculoskeletal disorders, including Hereditary Multiple Exostoses (HME) and Fibrodysplasia Ossificans Progressiva (FOP).

The Pacifici lab combines basic science studies with translational research. For example, lab staff conceived the idea of using synthetic retinoid agonists as therapeutics for FOP, leading to the identification of Palovarotene, which received FDA approval for FOP treatment in August 2023. The laboratory now focuses on identifying a therapeutic agent for HME.

The ideal candidate for this position is well-organized, detail-oriented, curious, and motivated, with a bachelor's degree in molecular and cell biology or a related field and previous experience working in a lab setting. Comfort with standard molecular biology techniques (PCR, running gels, etc.) and a proven ability to work in a team are critical. The successful candidate will have opportunities to contribute to several projects and resulting co-authorship on papers.

The applicant must be willing to work with mouse colonies daily and assist with their management (e.g., breeding, genotyping, record keeping, etc.). Prior experience with animal handling is preferred

What you will do

• Performs routine tests / experiments under the direction of principal investigator, supervisor or other designee
• Performs research procedures on experimental samples as directed
• Records and checks experiments/ results for completeness and accuracy
• Performs calculations and maintains appropriate log and lab notebooks
• Performs tasks that require familiarity with fundamental techniques and lab equipment
• May assist with planning specific research protocols and procedures
• Maintains office, lab area, solutions, reagents, supplies and equipment, disposes of specimens, media and other materials (using appropriate procedures)
• Assists in care and maintenance of lab equipment
• May coordinate schedules of tests and procedures
• Attends courses, seminars, and lab meetings to expand knowledge of research and laboratory techniques
• Records results, organizes data and maintains lab notebook in an organized manner
• Compiles and helps analyze data, prepares charts, graphs, and results of studies as directed
• Conducts literary searches as directed

Education Qualifications

• High School Diploma / GED Required
• Bachelor's Degree Preferred

Experience Qualifications

• At least one (1) year of related classroom experience or successful completion of a technical training program (eg. Wistar, WPSI) and research laboratory experience Required
• Experience with performing basic molecular biology techniques in a laboratory setting is strongly preferred.
• Experience working with mice colonies and performing breeding, genotyping, and record keeping is strongly preferred.

To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must be fully vaccinated against COVID-19 and receive an annual influenza vaccine. Learn more.

Employees may request exemptions for valid religious and medical reasons. Start dates may be delayed until candidates are immunized or exemption requests are reviewed.

EEO / VEVRAA Federal Contractor | Tobacco Statement