Research Techinican - Cancer Center

Massachusetts General Hospital
United States, Massachusetts, Boston
149 13th Street (Show on map)
Jan 21, 2025
The Corcoran lab seeks a highly motivated individual with a strong interest in pursuing a future academic career in science or medicine. This is an ideal position for a recent graduate who wants to gain an intense research experience before pursuing graduate or medical school. The candidate will take responsibility in basic science and translational research projects under close supervision of post-doctoral research fellows in the lab, as well as Dr. Ryan Corcoran (PI). Our current technicians have various roles within the lab. You will be introduced and trained on techniques used in the lab, depending on the departmental need. The current position available in the lab works mainly in the animal (mouse) facility with postdocs currently working on animal experiments, but the candidate will also have the opportunity to take part in other projects in the main lab. The Corcoran lab is involved in investigating new and effective therapies for gastrointestinal cancers, mainly colorectal, pancreatic and liver cancers. Our group is interested in elucidating novel mechanisms of resistance to targeted cancer therapeutics such as kinase inhibitors or immune checkpoint inhibitors (Ryan MB et al. Cell Reports 2022, Tian J et al. Nature Medicine 2023, Fece de la Cruz F et al. Cancer Discovery 2024, Tanaka N et al. Cancer Discovery 2024). Tissue culture techniques: maintenance of mouse/human cell lines in culture, cryopreservation, drug treatments, plasmid transfections, lentiviral transduction. Establish xenograft models, in vivo drug treatments, tumor isolation and processing for IHC. Perform standard molecular biology techniques (Western blotting, PCR, cloning, site-directed mutagenesis, CRISPR). Interpretation of experimental results. Interest on establishing new and optimizing existing techniques in the lab. Generation and maintenance of organoid cultures from patient biopsies. The General Hospital Corporation is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.