Associate Principal Scientist

At the heart of QIAGEN's business is a vision to make improvements in life possible.

We are on an exciting mission to make a real difference in science and healthcare. We are still the entrepreneurial company we started out as and have today achieved a size where we can bring our full power to many initiatives and to our presence across the globe.
Our most valuable asset are our employees - around 6000 in over 35 locations around the world. Our ambition is to ensure we have outstanding and passionate people working in the best teams and we are constantly looking for new talent to join us.
There are few players who have shaped the world of modern science and healthcare as much as QIAGEN, and we have only just started.
If you are looking to advance your career, are seeking new challenges and opportunities, enjoy working in dynamic and international, diverse teams and want to make a real impact on people's lives, then QIAGEN is where you need to be.

Join us. At QIAGEN, you make a difference every day.

The Associate Principal Scientist will join the PCR and Enzymes R&D team and have a leadership role, responsible for design, engineering, expression, and purification of enzymes and proteins with applications in life sciences and diagnostics fields. The ideal candidate will have experience in protein engineering, directed evolution, and be familiar with high-throughput enzyme engineering technologies. An expertise in designing expression DNA constructs.

Strong experience in protein expression and purification processes is critical. The person will be working in a cross-functional team and required to support both internal and external (customer defined) projects. This position requires a deep understanding of protein chemistry, molecular biology, and biopharmaceutical development processes

Responsibilities:

- Design, construct, express, and perform screening/selection assays for recombinant proteins.

- Participate in protein expression optimization and purification at different scales.

- Design and implement assays for enzyme characterization.

- Use and direct a range of methods for protein engineering including: rational design, structure analysis, directed evolution as well as machine learning to create novel enzymes or variants.

- Identify new opportunities and expand capabilities. Initiate and lead product development in developing innovative technologies and products.

- Train and/or supervise junior level Team members.

- Ph.D. degree in Biochemistry, Molecular Biology, Enzymology or related field with 5+ years of relevant experience in protein development or MS with 5-10 year of Biotech industry experience.

- Proven track record of successful protein engineering and development projects.

- Expertise in protein expression systems (e.g., bacterial, yeast, mammalian).and proficiency in purification techniques including ion exchange and affinity chromatography, dialysis, filtration, electrophoresis, and protein characterization and analytical methods such as thermal shift assay.

- Broad experience and knowledge in molecular biology techniques including PCR, gene assembly and cloning; protein engineering methods such as mutagenesis, fusion protein construction, and variant library generation methods.

- In-depth knowledge of enzymes used in molecular biology, especially polymerases and ligases, and molecular biology methods for nucleic acid analysis.

- Working experience with AKTA FPLC systems and knowledge of protein structural biology is a plus.

- Able to work in a fast-paced and collaborative team environment.

- Excellent analytical thinking, problem solving, timeline management and interpersonal skills.

- Strong organizational skills, and solid communication skills including oral, written and presentation techniques.

At the heart of QIAGEN are our people who drive our success. We act with passion, always challenging the status quo to drive innovation and continuous improvement. We inspire with our leadership and make an impact with our actions. We create a collaborative, safe and engaging workplace which forms the basis for high performing individuals and teams. We drive accountability and entrepreneurial decision-making and want you to excel your growth and shape the future of QIAGEN.

QIAGEN is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, and medical conditions related to pregnancy, childbirth, or breastfeeding), sex stereotyping (including but not limited to assumptions about a person's appearance or behavior, gender roles, gender expression, or gender identity), gender, gender identity, gender expression, national origin, age, mental or physical disability, ancestry, medical condition, marital status, military or veteran status, citizenship status, sexual orientation, genetic information, or any other status protected by applicable law.

QIAGEN complies with applicable laws regarding the confidentiality of employee health information and the reasonable accommodation of individuals with disabilities and/or sincerely held religious beliefs. Candidates who require accommodation should contact Benefits@QIAGEN.com. This policy is part of QIAGEN's ongoing efforts to support public health efforts and to ensure the safety and-well-being of its employees, customers, business partners, and community.