Senior Scientist, Capsid Engineering

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche.

The Senior Scientist, Capsid Engineering is a key member of the Discovery Research Team and participates in the development of Spark's gene delivery platforms. You will be critical for the development of novel AAV capsids with improved properties to enable the next generation of safer and more effective gene therapies.

The Opportunity:

• Ideate novel methodologies applying the latest advances in bulk, single-cell and spatial sequencing technologies towards high-throughput capsid library screening

• Develop and apply in vitro and in vivo screening approaches to identify AAV capsid variants with enhanced properties for clinical translation

• Execute experiments at the bench and analyze data to guide scientific decision-making

• Collaborate closely with machine learning scientists to leverage AI to accelerate capsid discovery efforts

• Support collaborations with internal and external parties

• Clearly communicate project progress and hurdles to team members, cross-functional collaborators and leadership

• Maintain up-to-date experimental records in the form of electronic lab notebook entries and study reports

• Present results in the form of publications and/or presentations at scientific meetings

Who You Are:

• PhD in a biological discipline and 3-5 years of relevant experience

• Strong analytical skills and problem-solving capabilities

• Deep knowledge of proven and emergent methods for targeted delivery of therapeutics

• Expertise in protein engineering and refinement techniques including rational design, directed evolution, saturation mutagenesis, affinity maturation, etc.

• Expertise in building platforms for high-throughput screening

• Expertise in molecular biology and protein analysis techniques such as molecular cloning, PCR/qPCR/dPCR, cell culture, protein production and purification, SDS-PAGE/WB, etc.

• Familiarity with next-generation sequencing technologies

• Familiarity with molecular biology software (e.g., Benchling, SnapGene, Geneious)

• Familiarity with developability considerations for biologics and/or gene therapy (e.g., stability, manufacturability, immunogenicity)

• Strong track record of scientific accomplishments in the form of publications and/or patents

• Demonstrated problem-solving skills and ability to work both independently and collaboratively

Preferred Qualifications:

• Familiarity with AAV biology and vectorology

• Experience with studies in laboratory animal models

• Familiarity with molecular visualization software (e.g., PyMOL, ChimeraX, etc.)

• Experience managing internal and external collaborations

The expected salary range for this position based on the primary location of Philadelphia is $103,400 to $192,000.Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.

This position also qualifies for the benefits detailed at the link provided below.

Benefits

A healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let's build a healthier future, together.

Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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