Senior/Principal Scientist (Computation)

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche.

Genentech is seeking a creative and highly accomplished scientist to develop and lead a research program in Computational Neuroscience/Neuroimmunology, focused on neurodegenerative and neuroinflammatory diseases such as Alzheimer's, Parkinson's, ALS, and multiple sclerosis, in the department of OMNI Bioinformatics within the Computational Sciences division.

Responsibilities include

• Strategic direction and execution of computational research into pathogenesis of neurodegenerative diseases using techniques such as gene expression, chromatin accessibility, human genetics, genetic screens and image analysis.

• Development and execution, with Translational Medicine, of reverse translation strategy to leverage clinical trial samples and data to identify new drug targets for residual disease

• Leading computational research in specialized areas such as neuroimmunology or microglial and lipid biology

• Nomination of new entries to the Neuroscience department Target Assessment Portfolio

• Serving as computational lead on pipeline programs as needed, supporting target validation, mechanism of action, safety, and biomarker studies.

• Collaborating within the Genentech Computational Sciences division to deploy cutting-edge AI models to solve the above problems

• In line with corporate strategy, contributing to and leading authorship of impactful scientific publications

The ideal candidate will have deep experience in the following types of analysis:

• Patient tissue or CSF/PBMC atlases

• Single-cell RNA-Seq, CITE-Seq, and immune repertoire (TCR/BCR)

• Proteomic datasets from neurodegenerative disease patient tissue or biofluids

• Use of human genetics to prioritize drug targets

• Mouse and cellular models of neurodegenerative disease

Who you are

Senior Scientist

• MD, PhD, MD/PhD or equivalent with in-depth training in a relevant field, and a deep understanding of both biological pathways relevant to neuroimmunology and computational methods to study these pathways.

• A track record of impactful scientific achievement as demonstrated by co-first/lead as well as contributing author publications.

• Excellent communication skills and evidence of success in complex, multidisciplinary environments are required.

Principal Scientist

• MD, PhD, MD/PhD or equivalent with in-depth training in a relevant field, deep understanding of biological pathways relevant to neuroimmunology and computational methods to study these pathways, as well as successful postdoctoral research, or 3 years post-PhD equivalent experience.

• A track record of impactful scientific achievement as demonstrated by co-first/lead as well as contributing author publications.

• Excellent communication skills and evidence of success in complex, multidisciplinary environments are required.

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Relocation benefits are available for this posting

The expected salary range for this position based on the primary location of California for Senior Scientist is $128,200 - 238,000, and for Principal Scientist is $150-700 - 279,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits