Research Associate

Roche Holdings Inc.
$64,100-119,000
United States, Washington, Seattle
123 South Main Street (Show on map)
May 29, 2025
At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position Roche Diagnostics acquired Stratos Genomics (https://www.stratosgenomics.com/) in 2020 for its unique chemistry, Sequencing by Expansion (SBX), that supports high signal-to-noise nanopore sequencing1. The Protein Engineering group at Roche Diagnostics Seattle is focused on innovative approaches to improve the performance of proteins in SBX, especially the Xpandomer synthase, a highly evolved DNA polymerase that makes SBX possible. We are looking for people who are excited about the significance of our technology, and who want to make SBX successful. The Opportunity: * Support the effort to produce and improve proteins involved in SBX * Contribute to the definition and timely achievement of project goals. * Proactively identify and troubleshoot problems * Perform data analysis and protocol development. * Maintain accurate, detailed and reliable laboratory records. * Communicate effectively with manager on project status, data analysis findings, and process deviations * Assist in maintaining laboratory cleanliness and organization. * Support management decisions and goals in a positive, professional manner. Please include a cover letter outlining why you want to work with us, your specific interest in our technology, and how you would contribute. Who You Are:** * B.S. degree in Biochemistry, Biophysics, Protein Science, Structural Biology, Genome Sciences or similar degree program * A minimum of 3 years of laboratory experience in the biotech industry or a research laboratory * You are comfortable with basic laboratory techniques (e.g., pipetting, sterile technique, solution preparation, etc.) * You have experience with preparing reagent solutions (ie. buffers, chemical stock solutions) * You have experience with standard molecular biology techniques (PCR, ligation, etc) Preferred Qualifications * You have experience with E. coli protein expression strains and protein purification * You have experience with protein mutagenesis, library methods, and variant screening * You have experience with protein structural analysis and prediction (PyMol, AI methods, Rosetta) * You have experience with online protein databases and how to extract useful information (BLAST, UniProt, RCSB, etc) * You have familiarity with next-generation DNA sequencing applications The expected salary range for this position based on the primary location of Washington State is $64,100-119,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed here: Benefits Relocation benefits are not available for this position Who we are A healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact. Let's build a healthier future, together. Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.