Scientist - Dr. Shirwan & Dr. Yolcu Laboratory

NextGen Precision Health

The Immunomodulation and Translational Research Program at NextGen Precision Health and the Department of Molecular Microbiology and Immunology at the University of Missouri focuses on developing novel biologics and their targeted delivery using various vehicles for immunomodulation. Our research aims to prevent and treat immune-related disorders, with a strong emphasis on type 1 diabetes and cancer immunotherapy and immunoprevention.

We are seeking a highly skilled and motivated Scientist (Microsurgery experience is desirable but not a requirement) to join our translational research team as a Research Scientist in the field of transplantation. The successful candidate will contribute to cutting-edge research focused on islet transplantation for the treatment of Type 1 Diabetes, utilizing both rodent and humanized mouse models. This is an exciting opportunity to contribute to high-impact research focused on improving outcomes for type 1 diabetes.

Candidates will have the chance to develop, execute, and evaluate experiments that assess the immunomodulatory efficacy of select biologics for various applications.

• Prevention of type 1 diabetes using the NOD mouse model and treatment with pancreatic islets or stem cell-derived beta cells.
• Prevention and treatment of cancer using transplantable and spontaneous cancer preclinical models, as well as HSC-humanized mouse models.
• Analyzing and organizing data for detailed record-keeping, grant, and manuscript submissions, and oral presentations at local, national, and international meetings.
• Contributing to ongoing research through active participation in lab discussions and training graduate students and technical personnel in necessary techniques.

We are looking for a candidate who is self-motivated, possesses strong creative and critical thinking skills, is detail-oriented, and is a goal-driven researcher. An exceptional team player is essential for this role.

Key Responsibilities:

• Perform advanced microsurgical procedures, including islet isolation and transplantation in small animal models.
• Design and execute experiments to evaluate graft function, immune tolerance, and rejection mechanisms.
• Conduct immunological assays including immunohistochemistry, multiparameter flow cytometry, and mixed lymphocyte reactions.
• Analyze and interpret complex datasets; contribute to manuscript preparation and grant proposals.
• Maintain detailed records and ensure compliance with institutional and federal animal care regulations.
• Train and mentor graduate students and technical staff in microsurgical and immunological techniques.
  

Monday - Friday, 8:00 a.m. - 5:00 p.m.

A Bachelor's degree in related/ relevant area and at least 3 years of experience from which comparable knowledge and skills can be acquired is necessary.

1. Ph.D., M.D., or equivalent in a relevant biomedical field.
2. Demonstrated expertise in microsurgery, particularly in islet transplantation techniques.
3. Proficiency in rodent and/or humanized mouse models.
4. Hands-on experience with immunohistochemistry, flow cytometry, and lymphocyte functional assays.
5. Strong critical thinking, problem-solving, and data analysis skills.
6. Excellent communication and organizational abilities.
7. Ability to work effectively in a multidisciplinary team environment.
   

Salary Range: $52,915.20 - $74,484.80 per year
Grade: GGS-010
University Title: Scientist
Internal applicants can determine their University title by accessing the Talent Profile tile in myHR.

Application, CV, References

Why Join Us?
This is a unique opportunity to contribute to transformative research with the potential to improve outcomes for individuals with Type 1 Diabetes. You will join a collaborative, forward-thinking team at the University of Missouri, with access to state-of-the-art facilities through the NextGen Precision Health Institution.

Columbia, Missouri:
Columbia, Mo., is known as an ideal college town, combining small-town comforts, community spirit, and low cost of living with big-city culture, activities, and resources. Home to nationally renowned public schools and other colleges and educational centers, Columbia is packed with restaurants and entertainment venues and hosts more than a dozen annual cultural festivals.

This position is eligible for University benefits. As part of your total compensation, the University offers a comprehensive benefits package, including medical, dental and vision plans, retirement, paid time off, short- and long-term disability, paid parental leave, paid caregiver leave, and educational fee discounts for all four UM System campuses. For additional information on University benefits, please visit the Faculty & Staff Benefits website at https://www.umsystem.edu/totalrewards/benefits.

Equal Employment Opportunity

The University of Missouri is an Equal Opportunity Employer.

To request ADA accommodations, please call the Director of Accessibility and ADA at 573-884-7278.