Post-Doctoral Associate

Protein engineering - E. coli metabolic regulation
Evolvability of proteins and emergence of new functions

We are using in vivo selections in E. coli to create de novo proteins from large libraries of randomized polypeptides that enable the bacteria to survive. We are also employing directed evolution to fine-tune the activities of the artificial proteins we have identified. An overarching theme for our group is the use of combinatorial protein libraries to tackle fundamental questions related to the origin and evolution of functional proteins. We are particularly interested in enzyme evolution and in elucidating basic principles of biocatalysis.

The applicant should have a Ph.D., expertise in bacterial metabolism, molecular biology and biochemistry, a strong publication record, excellent communication skills, and enthusiasm and motivation for science in a collaborative environment.

Our lab is part of the interdisciplinary BioTechnology Institute at the University of Minnesota - one of the largest research universities in the US. We are located in the heart of the vibrant Minneapolis-Saint Paul area, home to 3.4 Million people and urban center of the 'Land of Ten Thousand Lakes'.
The Postdoctoral Associate / Research Scholar (RS) will be responsible for the design and execution experimental work on bacterial metabolic analyses, the selection and directed evolution of proteins, as well as characterization of proteins. The RS will also be responsible for writing manuscripts communicating the analysis results, and is expected to perform research activities independently and in collaboration with other team members. The RS is expected to train undergraduate students, graduate students and technical staff. Finally, the RS participates actively in relevant seminars, journal clubs and symposia.

80 % Research
Designing, planning, carrying out and reporting on experimental work on protein engineering, the selection and directed evolution of proteins as well as characterization of proteins.

5 % Writing Publications
Drafting scientific manuscripts to communicate the results.

5 % Training and Supervising Others
Training and supervising other staff and students in the laboratory.

5 % General Laboratory Tasks
Performing laboratory maintenance, safety and organization tasks.

5 % Presentation of Research Results
Participating regularly in lab meetings, seminars, journal clubs and symposia.

Essential Qualifications The applicant should have a Ph.D., expertise in bacterial metabolism; molecular biology and biochemistry, a strong publication record, excellent communication skills, and enthusiasm and motivation to do science in a collaborative environment.

Preferred Qualifications: Expertise in selection and directed evolution of proteins.

Working at the University

At the University of Minnesota, you'll find a flexible work environment and supportive colleagues who are interested in lifelong learning. We prioritize work-life balance, allowing you to invest in the future of your career and in your life outside of work.

The University also offers a comprehensive benefits package that includes:

• Competitive wages, paid holidays, and generous time off
• Continuous learning opportunities through professional training and degree-seeking programs supported by the Regents Scholarship
• Low-cost medical, dental, and pharmacy plans
• Healthcare and dependent care flexible spending accounts
• University HSA contributions
• Disability and employer-paid life insurance
• Employee wellbeing program
• Excellent retirement plans with employer contribution
• Public Service Loan Forgiveness (PSLF) opportunity
• Financial counseling services
• Employee Assistance Program with eight sessions of counseling at no cost

Please visit the Office of Human Resources website for more information regarding benefits.

Please send a letter that specifically details why you would want to work with us and how your scientific interests and research experience could fit with our team. Send a document containing this letter, together with your CV, list of publications and the names of three references to Burckhard Seelig (seelig@umn.edu). The position is available immediately. Further information on the Seelig group: https://cbs.umn.edu/seelig-lab/home

To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-UOHR (8647).

The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.

The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu.

Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment.

The University of Minnesota, Twin Cities (UMTC)

The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.