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Postdoctoral Associates - Martin Lab

Howard Hughes Medical Institute (HHMI)
United States, California, Berkeley
December 11, 2023
Primary Work Address: 2033 Valley Life Sciences Building, Berkeley, CA, 94720-3140 Current HHMI Employees, click here to apply via your Workday account.

We are currently looking for two enthusiastic, self-motivated Postdoctoral Associates to work in the laboratory of Dr. Andy Martin at the University of California, Berkeley. The Martin lab's research focuses on the 26S proteasome and related protein translocases of the AAA+ ATPase family. In addition to processing misfolded, damaged, and incompletely translated proteins, the proteasome selectively degrades a large variety of regularly proteins that are involved in cell-cycle control, cell differentiation, signal transduction, transcription, and other vital processes, making it an essential mediator of post-translational control. More information can be found on the lab's website:

The Postdoctoral Associates will address exciting questions about the mechanisms of protein quality control, ATP-dependent protein unfolding and degradation, the ubiquitin-proteasome system, and ATPase motor function, and characterize the proteasome-degraded proteome. This is an excellent opportunity for candidates who have demonstrated the ability to work independently and have a track record of publications in peer-reviewed journals.

What we provide:
  • Opportunity to work in a small, diverse, and encouraging research environment.

  • Opportunities to go to domestic and international conferences in addition to departmental and HHMI retreats to present scientific findings. In the past year, our trainees have presented at Keystone (Vancouver, Canada), EMBO (Cavtat, Croatia), and Cold Spring Harbor (New York).

  • Opportunities to attend workshops for specialized training, such as instrumentation and data analysis.

  • Opportunity to mentor undergraduate researchers and build the next generation of scientists. Our lab is dedicated to teaching undergraduates through independent research projects.

  • Live in the beautiful San Francisco Bay area, with easy access to both city life and nature. Driving distance to many great National Parks and Lake Tahoe.

What you'll do:.

To be considered for the single-molecule-focused position, you should have expertise in:

  • Single-molecule TIRF microscopy or force measurements (optical or magnetic tweezers, fleezers); single-molecule instrumentation and data acquisition

  • MATLAB or Python coding for custom data analyses

  • In vitro biochemistry and enzyme kinetics

  • Recombinant protein expression and purification

To be considered for the mass spectrometry/proteomics-focused position, you should have expertise in:

  • Mass spectrometry and proteomics

  • Protein crosslinking

  • Cell biology or biochemistry

  • Recombinant protein expression and purification

What you bring:
  • A Ph.D. in biochemistry, biophysics, or a related field is required.

  • Ability to learn quickly and to work both independently and within a team.

  • Ability to work optimally with a wide variety of people from all backgrounds and at all levels of training.

  • Excellent oral and written communication skills.

  • High level of integrity and excellent interpersonal skills.

  • Positive attitude with a problem-solving, resilient approach.

Application Instructions
Please include the following items in one PDF as part of your application:

  • A cover letter including a summary of your research experience, your career goals, and your expertise in the relevant field(s).

  • Your curriculum vitae including a list of publications with brief (2-3 sentence) descriptions of your contributions to the published work.

  • Names and contact information for at least 3 references.

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet).

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job's principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word "may," the Essential Duties and Responsibilities described above are "essential functions" of the job, as defined by the Americans with Disabilities Act.

Compensation and Benefits

Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our site to learn more.

Compensation Range

$70,000.00 (minimum) - $80,500.00 (midpoint) - $91,000.00 (maximum)

Pay Type:


HHMI's salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal equity when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range.