Staff Research Associate

IND (Neurodegenerative Dis)

Full Time

78633BR

Job Summary

In the Staff Research Associate I/II (SRA I/II) position you would be an integral member of the Kampmann lab at the UCSF Institute for Neurodegenerative Diseases (IND). The Kampmann lab develops and uses innovative technologies to understand cellular and molecular mechanisms of human diseases and to discover new therapeutic strategies. A major focus of our research is on neurodegenerative diseases such as Alzheimer's and Parkinson's Disease. To this end, we have established a CRISPR-based functional genomics platform for genetic screens in both human iPSC-based and murine models of disease (Tian et al., 2019, Neuron; Ramani et al., 2023, bioRxiv). Our lab is part of the UCSF research community, the Chan Zuckerberg Neurodegeneration Challenge Network, the Tau Consortium and other collaborative research groups, providing us with an outstanding network of collaborators and access to other cutting-edge technologies. We are an interdisciplinary group of postdocs, graduate students and staff research associates. We are proud of our lab culture of intellectual curiosity, collaboration, support, diversity, and fun! Read more about our lab at kampmannlab.ucsf.edu.

In this position, you will be working as a member of a research team developing innovative, CRISPR/Cas9-based functional genomics approaches to understand the disease mechanism and to identify potential therapeutic strategies. You must be willing to work in a team, be organized, enjoy problem solving, and have strong communication skills. As you become familiar with our methodology, there will be opportunities to work independently on research projects. Based on your interest and expertise, you will be able to contribute to bioinformatics analysis of data as well. Past staff research associates have been integral co-authors on high impact publications in the lab.

Responsibilities primarily include working under the guidance of a graduate student or postdoc to conduct experiments using murine models of disease, primary neuronal cultures, and mammalian cell culture. This involves performing in vivo experiments such as delivering viral vectors into mice, collecting brain tissue, sectioning and immunostaining tissues, confocal imaging, flow cytometry, preparing samples for next-generation sequencing and analysis of the resulting datasets. The candidate will also support collaborative projects that require the use of the lab's CRISPR-based mouse in vivo screening platforms. Approximately 30% of the time will be spent on mouse colony maintenance tasks including setting up mouse breeding cages, weaning, tail/ear clipping, genotyping, promptly responding to mouse health concerns, updating the mouse inventory database, and other administrative tasks related to the mouse facility and IACUC protocols.

The final salary and offer components are subject to additional approvals based on UC policy.

To see the salary range for this position (we recommend that you make a note of the job code and use that to look up): TCS Non-Academic Titles Search (https://tcs.ucop.edu/non-academic-titles)

Please note: An offer will take into consideration the experience of the final candidate AND the current salary level of individuals working at UCSF in a similar role.

For roles covered by a bargaining unit agreement, there will be specific rules about where a new hire would be placed on the range.

To learn more about the benefits of working at UCSF, including total compensation, please visit: https://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html

Department Description

The Institute for Neurodegenerative Diseases (IND) at UCSF is pursuing a cutting-edge blend of basic science and clinical medicine to provide outstanding care to those suffering from neurodegenerative diseases. Founded in 1999, the IND is committed to creating therapeutics that will halt diseases such as Alzheimer's, Parkinson's, Creutzfeldt-Jakob disease and dementia resulting from traumatic brain injuries. The IND is poised to make serious contributions to this struggle at the frontier of neuroscience and medicine. The mission of the Institute for Neurodegenerative Diseases is to discover causes and develop cures for these illnesses with an innovative program of basic research and clinical medicine. The IND is directed by Nobel Laureate Stanley B. Prusiner, MD.

Required Qualifications

SRA I:

• B.A./B.S. degree in molecular/cell biology, neuroscience, or related field of science and knowledge of, or experience with, the basic techniques or methods required by the position; or an equivalent combination of education and experience
• Working knowledge of MS Office (Word, Excel, PowerPoint)
• Highly organized, attention to detail, demonstrated record-keeping abilities
• Excellent communication skills; good written English and skills to write reports

• One or more years of recent, directly related work experience following degree completion, utilizing the techniques or methods required by the position; or an equivalent combination of education and experience.

Preferred Qualifications

• Experience with mouse handling, including weaning and ear punching
• Experience with mammalian cell culture and primary neuronal culture
• Experience with sectioning and immunostaining of mouse brain tissues
• Experience in molecular biology, such as PCR, molecular cloning
• Experience in biochemistry, such as Western blotting
• Working knowledge of flow cytometry and microscopy
• Bioinformatics experience, such as analysis of imaging or next-generation sequencing data

About UCSF

The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world's leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.

Pride Values

UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence - also known as our PRIDE values.

In addition to our PRIDE values, UCSF is committed to equity - both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nurturing a culture that is welcoming and supportive, and engaging diverse ideas for the provision of culturally competent education, discovery, and patient care. Additional information about UCSF is available at diversity.ucsf.edu

Join us to find a rewarding career contributing to improving healthcare worldwide.

Equal Employment Opportunity

The University of California San Francisco is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.

Organization

Campus

Job Code and Payroll Title

009617 SRA 2 NEX

Job Category

Research and Scientific

Bargaining Unit

University Professional Technical Employees - Research Support Professionals Unit (UPTE-RX)

Employee Class

Career

Percentage

100%

Location

Mission Bay (SF)

Shift

Days

Shift Length

8 Hours

Additional Shift Details

M-F 9:00 - 5:30