Postdoctoral Associate -Xavier Lab - 40523

Broad Institute
United States, Massachusetts, Cambridge
Nov 24, 2024
Description & Requirements The Broad The Broad Institute of MIT and Harvard is one of the world's leading biomedical research institutes. It seeks to discover the molecular basis of major human diseases, develop effective new approaches to diagnostics and therapeutics, and disseminate discoveries, tools, methods, and data openly to the entire scientific community. Founded in 2004, the Broad Institute includes faculty, professional staff, and students from throughout the MIT and Harvard biomedical research communities, with collaborations spanning the globe. Job description We are seeking highly motivated applicants for postdoctoral positions in microbiome in health and disease. PhD in Computational biology, Statistics, Mathematics or a closely related field Positions offer opportunities to learn cutting edge technologies and apply new skills to impactful scientific questions. We encourage intellectual growth through multidisciplinary collaboration. Demonstrated productivity and active publication are strengths. Applications should be directed to Ramnik Xavier (rxavier@broadinstitute.org) The human microbiome has co-evolved with its host to establish a stable homeostatic relationship with hallmark features of mutualistic symbioses. With emerging evidence implicating the microbiome as a potent disease modifying factor across numerous tissues and disease states, we aim to decode molecular interactions between the microbiome and host that modulate health and disease. Projects involve discovery of chemical dark matter in the microbiome and functional characterization of bioactive metabolites to identify host cellular responses and molecular targets that mediate interactions between the microbiome and the host immune system. Additional projects focus on education of the adaptive immune system by the microbiome. Discovery of B and T cell antigens derived from the microbiome allows for tracking antigen-specific lymphocytes and functional characterization of dynamic shifts in regulatory versus inflammatory responses. ( PMID: 38569543, PMID: 36563663, PMID: 37301199, doi: https://doi.org/10.1101/2023.10.23.563620) Qualifications PhD in statistics, mathematics, genetics, bioinformatics or a closely related field, with solid training in analytical methods Excellent computational/programming and analytical skills Demonstrated experience in statistical research and/or genetics, publication in scientific journals and demonstrated ability to communicate scientific ideas through verbal presentations.