Biomedical Modeler or Senior Biomedical Modeler & Pharmacometrician

The Center for Translational Pharmacology (CTP) at St. Jude Children's Research Hospital has two open positions for highly motivated and creative individuals at the Senior Biomedical Modeler and Biomedical Modeler level within the Department of Pharmacy and Pharmaceutical Sciences. The CTP is the nexus for clinical pharmacology at St. Jude, where the clinical enterprise has expanded beyond oncology to programs that include non-malignant hematology, cell therapy, infectious diseases, neurologic diseases, epidemiology, and psychology.

Scientists with expertise in innovative pharmacometric and statistical approaches for pharmacokinetic and pharmacodynamic data analysis are encouraged to apply. The biomedical modeling group is integral to clinical trial design and interpretation, and scientists are expected to contribute to manuscript preparation with appropriate credit on publications. Additional opportunities for scholarship through novel modeling approaches are encouraged and CTP scientists will have the opportunity for continued professional development through training and participation in scientific conferences. The CTP provides a highly interactive environment with collaborative opportunities for meaningful contributions to the design of all pharmacology aspects within the context of phase 0, phase I, and phase II clinical trials. CTP biomedical modelers will interact with faculty in the Department of Pharmacy and Pharmaceutical Sciences and clinicians across all clinical research programs.

Biomedical Modeler

Job Responsibilities:

• Provide pharmacometric expertise to researchers as designated by collaboration areas in all aspects of conducting pharmacometric and/or statistical analyses for basic, translational, and/or clinical studies. Assists with acquiring or acquires the data for modeling and verifies the data prior to modeling.
• Design, coordinate, supervise and implement quality control procedures for both clinical and preclinical research data. Develop appropriate methods to ensure the validity of pharmacometric research data. Works with Lab database to ensure validity of pharmacometric research data.
• Assist in the preparation of pharmacometric results for meeting abstracts, posters, and peer-reviewed manuscripts. May serve as a co-author or in select cases as a primary author on biomedical modeling related publications.
• Provides education and training in pharmacometric techniques to individuals as assigned by the supervisor.
• Performs other related duties as assigned in order to meet the goals and objectives of the department and institution.

Minimum Education and/or Training:

• Bachelor's degree in mathematics, engineering, or computer science with advanced training in pharmacometrics and/or quantitative systems biology modeling is required.
• Master's degree or PhD in mathematics, biomedical engineering or related field with advanced training in pharmacometrics and/or quantitative systems biology modeling is preferred.

Minimum Experience:

• Four (4) years of relevant experience in pharmacometrics, biostatistics, and/or a relevant research field.
• With a PhD, three (3) years of relevant experience in a pharmacometric or biostatistics, and/or a relevant research field is required.
• Experience in standard pharmacometric and statistical methods, software, and study design is preferred.

Compensation for Biomedical Modeler: $94,640.00/yr. - $169,520.00/yr.

Senior Biomedical Modeler

Job Responsibilities:

• Provide pharmacometric expertise to researchers as designated by collaboration areas in all aspects of conducting pharmacometric and/or statistical analyses for basic, translational, and/or clinical studies. Assists with acquiring or acquires the data for modeling and verifies the data prior to modeling.
• Understand, integrate, and use widely accepted as well as novel approaches to pharmacometric modeling and statistical analysis (e.g., R, Matlab).
• Utilize routine pharmacometric software (e.g., ADAPT, NONMEM, Monolix, WinNonlin, SimCYP, PK Sim, MOBI, GastroPlus) to conduct noncompartmental as well as compartmental analyses.
• Introduce novel and state-of-the-art pharmacometric modeling techniques as project warrants.
• Participate in the development of software interfaces for clinical programs necessary for pharmacokinetic and drug dosage adjustment for clinical protocols.
• Design, coordinate, supervise and implement quality control procedures for both clinical and pre-clinical research data. Develop appropriate methods to ensure the validity of pharmacometric research data. Works with Lab database to ensure validity of pharmacometric research data.
• Prepare pharmacometric results for meeting abstracts, posters, and peer-reviewed manuscripts and serve as a co-author or in select cases as a primary author on biomedical modeling related publications.
• Provide pharmacometric expertise to researchers as designated by collaboration areas in all aspects of conducting pharmacometric and/or statistical analyses for basic, translational, and/or clinical studies. Assists with acquiring or acquires the data for modeling and verifies the data prior to modeling.
• Understand, integrate, and use widely accepted as well as novel approaches to pharmacometric modeling and statistical analysis (e.g., R, Matlab).
• Utilize routine pharmacometric software (e.g., ADAPT, NONMEM, Monolix, WinNonlin, SimCYP, PK Sim, MOBI, GastroPlus) to conduct noncompartmental as well as compartmental analyses.
• Introduce novel and state-of-the-art pharmacometric modeling techniques as project warrants.
• Participate in the development of software interfaces for clinical programs necessary for pharmacokinetic and drug dosage adjustment for clinical protocols.
• Design, coordinate, supervise and implement quality control procedures for both clinical and pre-clinical research data. Develop appropriate methods to ensure the validity of pharmacometric research data. Works with Lab database to ensure validity of pharmacometric research data.
• Prepare pharmacometric results for meeting abstracts, posters, and peer-reviewed manuscripts and serve as a co-author or in select cases as a primary author on biomedical modeling related publications.
• Provides education and training in pharmacometric techniques to individuals as assigned by the supervisor.
• Perform other duties as assigned to meet the goals and objectives of the department and institution.
• Maintains regular and predictable attendance.

Minimum Education and/or Training:

• Bachelor's degree in mathematics, engineering, or computer science with advanced training in pharmacometrics and/or quantitative systems biology modeling in required.
• Master's degree or PhD in mathematics, biomedical engineering or related field with advanced training in pharmacometrics and/or quantitative systems biology modeling is preferred.

Minimum Experience:

• Five (5) years of relevant experience in pharmacometric or biostatistics, and/or a relevant field of research.
• Experience in standard and advanced pharmacometric and statistical methods, software, and study design is preferred.

Compensation for Senior Biomedical Modeler: $104,000.00/yr. - $186,160.00/yr.

Compensation

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Diversity, Equity and Inclusion

St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment.

Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.

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