Bioinformatics Research Scientist (TIRTL Bluesky)
 St. Jude Children's Research Hospital | |
 United States, Tennessee, Memphis | |
| 262 Danny Thomas Place (Show on map) | |
 Nov 17, 2024 | |
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The Bioinformatics Research Scientist is responsible for designing, developing, improving, modifying, and operating data analysis pipelines. Manages projects and coordinates other efforts related to analysis and infrastructure as directed.
Bluesky Tracking the Immune Repertoire of Tumor Lymphocytes (TIRTL) is seeking a Bioinformatics Research Scientist with experience in High Throughput Sequencing data analysis. Experience in immune repertoire data analysis is preferred, but not required. The aim of the TIRTL initiative is to establish a research lab responsible for a) sample selection and study design, b) experimental protocols for data generation, and c) data analysis specifically for lymphocyte TCR and BCR repertoire sequencing. In parallel to the clinical genomics pipeline, we will use excess primary tumor samples to perform targeted sequencing of tumor-associated B cell, alpha-beta T cell, and gamma-delta T cell repertoires. Using a combination of bioinformatic and computational approaches, we will integrate these data with the mutation profiles of the tumors. The objectives of the analysis include: 1) Correlation of antigen receptor features with tumor mutations; 2) identification of anti-tumor specific responses; 3) identification of tumorigenic cell specificities that promote tumor development and growth; and 4) identification of correlates of therapeutic efficacy or failure. In addition to these core objectives, we will extend the pipeline to include analysis of valuable and clinically relevant sample sets such as HCT patients experiencing GVH, and aplastic anemia subjects. These objectives align with multiple elements of our strategic plan, including developing immunotherapy programs and expanding data science initiatives. In this position, you will develop novel computational tools to analyze TCR/BCR repertoire sequencing data & identify tumor-infiltrating lymphocytes with therapeutic potential. We are looking for a candidate experienced in High Throughput Sequencing data analysis and custom software development. You will also participate in programming robots to automate lab operations Job responsibilities:
Minimum Education and/or Training: State the minimum education and/or training required.
Minimum Experience: State the minimum years of experience required to do this job successfully.
Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Bioinformatics Research Scientist (TIRTL Bluesky).Explore our exceptional benefits! Diversity, Equity and Inclusion St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude. | |