Postdoctoral Research Associate-Hematology

Dr. Crispino's laboratory studies the biology of normal and malignant hematopoiesis with an emphasis on the factors that drive progression of benign disorders to acute leukemia. Research in the lab ranges from the basic science of transcription to translational research aimed at developing treatments for blood disorders. A current major focus of the lab is to understand the increased risk of leukemia in children with Down syndrome and the role of GATA1 mutations and DYRK1A in oncogenesis. Another area of intense study is defining the mechanisms by which myeloproliferative disorders and myelodysplastic syndrome progress to acute myeloid leukemia. Finally, there is a major effort to understand the role of GATA1 in erythropoiesis. We seek an ambitious, motivated, and friendly postdoctoral scientist who has the desire to help advance our understand of blood disorders and improve the lives of patients.

Dr. Crispino has led a highly productive and well-funded laboratory, which is supported by an NCI R35 Outstanding Investigator Award, for more than 20 years. Recent publications include ones inthe Journal of Clinical Investigation,Cancer Discovery, andBlood. He is well known for his work on the increased incidence of leukemia in children with Down syndrome, on the contributions of GATA1 to red cell and megakaryocyte development, and on the role of megakaryocytes in myelofibrosis. He has mentored over 30 post-docs, clinical fellow, and PhD students, many of whom have moved to independent academic positions. He relocated his laboratory from Northwestern University in Chicago to St. Jude Children's Research Hospital in the summer of 2020. He is excited to be part of the outstanding scientific environment at St. Jude and to train the next generation of hematology researchers.

Candidates should have recently earned/expect to earn a Ph.D. and have published at least one first author primary research paper in a high impact peer reviewed journal. They should have experience in tissue culture and molecular biology. Experience with flow cytometry and animal models is a plus.

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