Post-Doctoral Research Fellow- Medical Oncology- Lab of Dr. Claudia Capparelli

We are seeking a Postdoctoral Fellow to join our research program to investigatethe mechanisms underlying tumor heterogeneity and plasticity in melanoma with the goal of identifying noveltreatment strategies for melanoma patients.Our research aims to identify and target pathway dependencies and vulnerabilities in drug tolerant persister cells in order to prevent metastasis and improve treatment options for melanoma patients. Additional research interests include: i) characterizing alterations that occur in the Extra Cellular Matrix during the establishment of drug tolerance and ii) investigate therapies that mediate changeswithin the tumor immune microenvironment as an approach to improve response to immunotherapies.Understanding alterations in the tumor microenvironment could ultimately lead to the identification of novel therapeutic approaches for the treatment of melanoma.Our research ranges from fundamental molecular mechanisms to clinical applications utilizing molecular and cellular biology, 3D cell culture, flow cytometry, omics studies, and mouse models.

For more information please check out:https://research.jefferson.edu/labs/researcher/capparelli-research.html

PhD or equivalent

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Jefferson includes Thomas Jefferson University and Jefferson Health, a dynamic university and health system with broad reach across the Delaware Valley. Jefferson is the second largest employer in Philadelphia and the largest health system in Philadelphia based on total licensed beds.

Through the merger of Thomas Jefferson University and Philadelphia University in 2017, our University includes ten colleges and four schools. We are an NCAA Division II university and an R2 national doctoral university offering undergraduate and graduate-level programs that provide students with a forward-thinking education in architecture, business, design, engineering, fashion and textiles, health, medicine and social science.

Jefferson Health, the clinical arm of Thomas Jefferson University, has grown from a three-hospital academic health center in 2015, to an 18-hospital health system through mergers and combinations that include hospitals at Abington Health, Aria Health, Kennedy Health, Magee Rehabilitation and Einstein Healthcare Network. We have over 50 outpatient and urgent care centers; ten Magnetreg;-designated hospitals (recognized by the ANCC for nursing excellence); the NCI-designated Sidney Kimmel Cancer Center (one of only 70 in the country and one of only two in the region); and one of the largest faculty-based telehealth networks in the country. In 2021, Jefferson Health became the sole owner of HealthPartners Plan, a not-for-profit health maintenance organization in Southeastern Pennsylvania. We are the first health system regionally to create an aligned payer-provider partnership.

Jeffersonrsquo;s mission, vision and values create an organization that attracts the best and the brightest students, faculty, staff, and healthcare professionals, as well as the most visionary leaders to drive exceptional results.

• OUR MISSION: We improve lives.
• OUR VISION: Reimagining health, education and discovery to create unparalleled value
• OUR VALUES: Put People First, Be Bold amp; Think Differently and Do the Right Thing

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