Modeling & Simulations Engineering Senior Scientist

Vertex Pharmaceuticals Incorporated
United States, Rhode Island, Providence
Sep 30, 2024
Job Description General Summary: The M&S Engineering Senior Scientist will develop physical, mathematical and computational models based on structural mechanics, fluid dynamics, and thermodynamics. The incumbent will generate mechanistic and data-driven insights that will accelerate design, manufacturing, and failure mode analysis of an immunoprotective device solution for cell and gene therapies. Key Duties and Responsibilities: Apply engineering skills, data analysis, computational modeling to optimize design and fabirication of an implantable combination product. Manage complete modeling project operations entailing requirement gathering, scoping, input data requirements, problem solving, verification, validation, and documentation. Initiate & lead brainstorming and ideation sessions to develop device design and manufacturing concepts. Develop experimental designs in collaboration with other engineers and scientists. Work with Device Fabrication team on assessing the manufacturability of the device designs via rapid prototyping methods and accelerate design ideation phase via fit-for-purpose models and simulations. Collaborate with clinical and preclinical teams to understand anatomical constraints and eliminate device mechanical failure modes. Effectively communicate modeling results and findings at multiple levels in the organization through project status meetings, presentations, and reports. Knowledge and Skills: Expertise in the mechanics and thermodynamics of polymers including plastics, hydrogels, and rubber materials. Experience in multiphysics modeling of phase transition in engineering and biological materials Familiarity with implantable medical devices, and understanding of tissue mechanics. Expertise in Computer Aided Design (e.g. SolidWorks), Finite Element Method (e.g. ANSYS Mechanical, or COMSOL), Finite Volumes Method (e.g. Fluent, or Star-CCM+), and familiarity with scientific machine learning. Excellent knowledge of mechanical engineering design concepts, ASTM standards, design control, and tolerance analysis with hands-on experience with materials test systems (i.e. Instron) Quickly adapt to evolving priorities, rapidly acquire new skills, and stay informed on new methods and approaches. Strong verbal and written communications skills with ability to effectively communicate at multiple levels in the organization through project status meetings, presentations, and reports. Education and Experience: Bachelor's degree and 8+ years of experience or a Master's degree and 5+ years of experience or a PhD and 2-5 years of experience, or the equivalent combination of education and experience. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com