Scientific Investigator, Translational Science

Despite the listing of GSK-Upper Providence PA as the primary job location candidates will be considered equally from Upper Providence (USA) and Stevenage (UK) sites.

As the Scientific Investigator in the Translational Science Unit within RI RU, you will play a critical role in bridging preclinical target and asset validation and early clinical proof of concept studies by designing and performing translational assays in human-derived cells, tissues, and surgical discard organs.

Key Responsibilities:

This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following...

• Working closely with other RI RU lines (biology, translational research, clinical) and Precision Medicine, design, optimize, and execute preclinical studies to strengthen target-disease hypotheses and provide evidence for GSK translational pillars by using human ex vivo samples in RI RU disease areas of interest.

• Apply expertise in several of the following capabilities: gene/protein expression analysis, next-generation sequencing, proteomics, metabolomics, ELISA/MSD/Quanterix/protein assays, flow cytometry, spatial 'omics, emerging technologies and commercial platforms (e.g., OLink/SomaScan).

• Provide technical and disease input into the translational strategy for one or more projects and influence project direction through interpretation and integration of relevant project and other data.

• Utilize a growing internal and external network to build translational expertise in technology and disease areas; act as a go to expert on specific technologies and/or disease mechanisms.

• Work closely with preclinical statistics and other relevant teams to ensure robust study design of experiments.

• Effectively trouble-shoot assays and, when necessary, develop alternative approaches.

• Identify and progress collaborations with external partners, including academic institutions and contract research organizations, to leverage expertise and resources to support translational studies.

• Stay up to date with the latest scientific literature and emerging technologies relevant to translational research.

• Present findings to internal teams, stakeholders, and governance in a balanced, clear, and precise manner.

• Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines.

• Ensure compliance with all applicable laws, regulations, and ethical standards in the conduct of translational research.

• Foster a culture of innovation, collaboration, and continuous learning within the translational research team and across the organization.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• PhD in a relevant scientific discipline with at least 4 years of relevant work experience, or Master's degree with at least 7 years of relevant work experience, or Bachelor's with at least 10 years of relevant work experience.

• Disease area expertise in at least one of these disease areas: neurodegeneration, hepatology, and/or renal.

• Experience in human systems using cellular/molecular biology, assays, and analytic methods including gene/protein expression analysis, proteomics, and metabolomics.

• Experience in several of the following technical capabilities: bioassay development and analysis (ELISA/MSD/Quanterix), flow cytometry, DNA and RNA sequencing technologies, spatial omics, emerging technologies, and commercial platforms (e.g., OLink/SomaScan).

• Experience in RI RU relevant disease mechanisms and pathways and the ability to apply this knowledge to translational research and biomarker development.

• Experience in data analysis and bioinformatics tools for the interpretation of large-scale datasets.

• Experience with scientific innovation as evidenced by effective support of drug discovery projects, peer-reviewed publications, conferences, internal reports, technical evidence documents or patents.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Excellent problem-solving skills and ability to critically analyze scientific data.

• Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner.

• Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards.

• Able to independently define strategic approach to tackle specific project or department goals.

• Ability to work independently as well as collaboratively in a team-oriented environment.

• Resourcefulness to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities.

• Experience in the design and execution of biomarker-driven clinical trials and the development of companion diagnostics.

• Knowledge of regulatory guidelines and compliance requirements related to translational research and clinical development.

#LI-GSK

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.