UCI Environmental and Occupational Health - Postdoctoral

UC Irvine is one of ten campuses of the highly regarded University of California system. With approximately 37,000 students, 1,500 ladder-rank faculty members, a highly ranked medical school, and over $500 million per year of extramural grant funding, our campus offers a wealth of opportunities for research collaboration and is ranked among the top 10 public universities in the US. UC Irvine is building on excellence in its Program in Public Health to develop a School of Public and Population Health. Accredited by the Council on Education for Public Health since October 2012, our rapidly growing Program in Public Health offers BA, BS, MPH, and PhD degrees in a variety of emphasis areas including environmental health sciences and was recently ranked among the top 40 schools and programs in public health in the country by U.S. News and World Report. More information is available on our web site at http://publichealth.uci.edu/.

The Department of Environmental and Occupational Health at University of California, Irvine (UCI) invites applications for a full-time post-doctoral researcher position who will be involved in a study elucidating the role of microglia in Alzheimer's disease using animals and cell culture models. UCI is one of the top-ranked research universities located in Southern California, United States. Dr. Masashi Kitazawa laboratory focuses on understanding the pathogenic role of genetic and environmental interactions in Alzheimer's disease (AD), with particular interest in the impact of neuroinflammation elicited by aging and genetic predispositions, as well as by environmental risk factors, such as exposure to air pollution and toxic metals. Through understanding the key neurodegenerative mechanisms by the gene x environmental interactions, the lab also makes effort on developing better animal models and evaluating potential therapeutic strategies using these animals. Techniques including rodent behavior tests, immunoblots, immunohistochemistry, various biochemical assays, and cell culture-based assays are routinely performed in the lab. More details about Dr. Kitazawa's work can be found at https://www.faculty.uci.edu/profile.cfm?faculty_id=6223

The selected applicant will work primarily on the NIH-funded study to investigate how spleen tyrosine kinase (SYK) in microglia controls microglia activation and the progression of AD neuropathology in animal models and human iPSC-derived microglia. The research will utilize iPSCs, various in vitro assays, such as cell viability assay, cytokine assays, phagocytosis assay, ELISA and immunocytochemistry, and in vivo animal models of AD. The post-doctoral researcher will work under the supervision of Dr. Masashi Kitazawa.

-Funding is available for a minimum of 3 years.

-Salary will be based on qualifications and experience.

-Start date: Available immediately or negotiable.

1) A cover letter that includes a description of current research, future plans for research and professional goals

2) A curriculum vitae

3) 2-3 samples of scholarly writing (published, under review or in preparation)

4) Name 3 individuals to request a letter of reference.

Please send any questions regarding this search to Dr. Kitazawa (kitazawa@uci.edu).

Duties will include:

1) work closely with Dr. Kitazawa and other team members to establish iPSC maintenance, differentiation and optimization to neurons;

2) involve in animal breeding, behavior testing, and drug treatment regimens,

3) publish original research in high impact peer-reviewed journals;

4) present relevant work at various scientific meetings; and

5) support the writing of progress and final report.

Requirements include:

* Doctoral degree in neuroscience, toxicology, pharmacology, biology, chemistry or relevant field.

* No more than 3 years of post-doctoral experience.

* Prior experience in animal models and/or iPSC are highly encouraged.

* Excellent data analysis skills and familiarity in statistical analysis software.

* Excellent communication skills (oral and written) in English.

* Ability to work independently with occasional supervision.

* Demonstrated publication record in neuroscience, toxicology or pharmacology.

* Ability to take initiative, creativity, attention to details and commitment to producing high quality work.

• 3 required (contact information only)

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC anti-discrimination policy.

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.