Director, Health Economics & Outcomes Research

Job Description

Vertex is a global biotechnology company that operates at the forefront of scientific innovation. We have brought multiple breakthrough therapies to patients with Cystic Fibrosis (CF) and advanced novel treatments such as CASGEVY, a gene therapy for sickle cell disease and beta-thalassemia, and JOURNAVX, the first new class of medicine for moderate-to-severe acute pain in more than two decades. Our research pipeline spans more than a dozen programs targeting the underlying mechanisms of serious diseases, including B cell-mediated renal diseases, APOL-1 mediated kidney disease (AMKD), chronic pain, DM-1, and cell therapies for Type 1 diabetes, among others.

The Health Economics and Outcomes Research (HEOR) team works globally and cross-functionally to shape strategy and generate evidence that demonstrates the value of Vertex therapies, supporting access, reimbursement, and decision-making at every stage of the product lifecycle.

Vertex is seeking a Director of Global HEOR to lead and execute health economics and outcomes research (HEOR) activities for the pain program, with a focus on prospective, non-interventional studies to support commercialization strategies. This role will combine strategic oversight with hands-on execution to shape the HEOR strategy, guide study design, and ensure high-quality delivery of research that demonstrates the value of Vertex therapies, beginning with moderate-to-severe acute pain. The Director will work closely with cross-functional colleagues, vendors, and external experts to manage projects from concept development through publication, balancing scientific rigor, operational excellence, and business impact. This role reports to the senior director, global HEOR pain.

• Strategy & Leadership
  • Define and execute the HEOR strategy for prospective non-interventional research aligned with pain program strategy.
  • Represent HEOR perspectives in cross-functional forums and with external partners, aligning research with program and business objectives.
• Study Design & Execution
  • Lead, with vendor support, the development of protocols, investigator brochures, informed consent forms (ICFs), case report forms (CRFs), statistical analysis plans (SAPs), and technical reports.
  • Lead Study Execution Teams (SETs), ensuring efficient, high-quality study execution.
  • Manage study operations, including timelines, deliverables, and budgets; ensure issues are identified and resolved proactively.
  • Support vendor selection and contracting.
  • Coordinate cross-functional review and approval of study-related documents and outputs.
• Data Interpretation & Communication
  • Oversee data analysis, interpretation, scientific rigor, and communication of results, ensuring contextually relevant.
  • Lead development of presentations, manuscripts, and other dissemination activities.
  • Provide clear updates to internal stakeholders and cross-functional teams on study progress and insights.
• Collaboration & Representation
  • Partner with internal stakeholders, such as Medical Affairs, to ensure alignment in study design, execution, and dissemination.
  • Represent Vertex externally with investigators, collaborators, and scientific experts in protocol development and study conduct.

• Advanced degree (PhD, PharmD, MD, or MS with significant experience) in epidemiology, health economics, clinical research, health services research, public health, or related field.
• 10+ years of experience in HEOR, clinical research, or observational studies in academia, industry, or equivalent.
• Proven experience leading the design, execution, and analysis of prospective and non-interventional studies, including site feasibility, case report form development, and recruitment.
• Strong knowledge of Good Clinical Practice (GCP), biostatistics, clinical research methods, and study design.
• Demonstrated ability to manage vendors, budgets, and complex project deliverables.
• Experience preparing publications and presenting scientific findings.

• Strategic thinker with the ability to connect evidence generation to business and clinical priorities.
• Hands-on project leader with strong execution skills and attention to detail.
• Excellent oral and written communication skills; able to translate complex science into clear, actionable insights.
• Strong organizational and problem-solving skills with ability to manage multiple priorities simultaneously.
• Collaborative team player who builds effective partnerships internally and externally.
• Ability to thrive in a fast-paced, matrix environment and balance both independent and team-based work.

Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com