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Senior Manager, General Ledger Accounting

Vertex Pharmaceuticals Incorporated
paid time off, 401(k)
United States, Massachusetts, Boston
50 Northern Avenue (Show on map)
Sep 11, 2025

Job Description

Position Summary:

  • Vertex Pharmaceuticals is seeking a highly motivated and experienced Senior Managerbased in Boston, Massachusetts to join its global accounting team
  • The role will oversee theglobal month-end close process, manage key relationships withFinance, and leadprocess and technology transformation initiativesacross the global accounting function
  • The successful applicant will have strong leadership experience and be responsible for managing a small, high-performing team across multiple time zones, and play a key role in ensuring the integrity, timeliness, and efficiency of global financial reporting
  • This position involves working collaboratively with stakeholders across multiple teams globally and is highly visible within the organization

Key Duties and Responsibilities:

Month-End Close & Accounting Oversight:

  • Lead and coordinate the global month-end close process (including various subledgers and accounting systems), ensuring accurate and timely completion across the business
  • Oversee the preparation and review of the monthly accounting transactions including journal entries, accruals, and general ledger reconciliations in accordance with US GAAP and global accounting policies
  • Advise on the accounting treatment for non-recurring transactions, partnering with stakeholders to provide clear effective communication to management
  • Own and drive improvements to the monthly financial reporting process, including detailed variance analysis across key P&L and Balance Sheet accounts

Business Partnership:

  • Develop and maintain strong working relationships withFinance Business Partnersacross various functions and geographies to ensure accurate intercompany and consolidated reporting
  • Collaborate closely with FP&A teams toalign accruals and financial estimates, and ensure financial accuracy
  • Work closely with Tax, Treasury and other Accounting departments to proactively resolve issues and drive alignment on accounting matters

Process & Systems Improvement:

  • Drive process standardization, andcontinuous improvementacross the global accounting function
  • Identify opportunities and design solutions for automating processes and driving improved reporting capabilities
  • Monitor and evaluate internal controls, making recommendations to strengthen the control environment and minimize risk
  • Champion a culture of innovation and curiosity within the team

Team Leadership:

  • Manage, mentor, and develop two to three direct reports
  • Set clear goals, provide regular feedback, and support professional development of the team
  • Foster collaboration across a distributed team and promote a culture of accountability, curiosity and continuous learning

Knowledge and Skills:

  • Strong technical accounting skills and proven experience leading or playing a key role in themonth-end close process
  • Strong knowledge of US GAAP, SOX compliance and internal controls
  • Proven track record of leadingprocess improvement and systems initiativesin finance and accounting
  • Strong communication and interpersonal skills, with the ability to collaborate effectively with senior management and external partners
  • Working knowledge of EBS environments (Oracle or SAP). Familiarity with Blackline and Workiva is a plus
  • A self-starter with a hands-on workstyle, strong work ethic and can-do attitude
  • Ability to build and foster strong relationships within the CFO organization and throughout the organization
  • Continuous improvement mindset, with a passion for leveraging technology to enhance processes
  • Proven experience in managing and developing a team
  • Experience in the pharmaceutical, biotechnology, or life sciences industries is a plus

Education and Experience:

  • Bachelor's Degree (or equivalent) in Finance or Accounting
  • Qualified Accountant (CPA) from a professional practice background
  • Big 4 experience is strongly preferred
  • 6+ years of experience in field
  • Strong technical accounting skills and proven experience leading or playing a key role in themonth-end close process
  • Strong knowledge of US GAAP, SOX compliance and internal controls
  • Proven track record of leadingprocess improvement and systems initiativesin finance and accounting
  • Strong communication and interpersonal skills, with the ability to collaborate effectively with senior management and external partners
  • Working knowledge of EBS environments (Oracle or SAP). Familiarity with Blackline and Workiva is a plus
  • A self-starter with a hands-on workstyle, strong work ethic and can-do attitude
  • Ability to build and foster strong relationships within the CFO organization and throughout the organization
  • Continuous improvement mindset, with a passion for leveraging technology to enhance processes
  • Proven experience in managing and developing a team
  • Experience in the pharmaceutical, biotechnology, or life sciences industries is a plus

Pay Range:

$124,800 - $187,200

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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