Technical Development Staff Scientist

As part of Pharma Technical Development (PTD) our organization is committed to deliver the Pharma ambitions by bringing game-changing therapies from clinical phase I into the market to serve every patient, every day. Our core business is to develop safe, innovative and effective drugs using cutting edge technologies for manufacturing process (Drug Substance and Drug Product), clinical supply, formulation, device, packaging, and analytical development.

Together with our partners, Global Biologics Bioprocess Development develops robust, efficient, and sustainable bioprocesses including Cell Line & Media Development, Cell Culture & Fermentation, and Purification Development.

The Cell Culture Development US organization provides innovative technologies and strategic support for development and commercialization of Genentech and Roche's biologic portfolio, including standard monoclonal antibodies as well as complex and modified proteins such as antibody drug conjugates and bispecific antibodies. The Roche/Genentech biological portfolio spans late stage research (LSR), preclinical, clinical, and initial marketing authorization.

The department of Cell Culture and Bioprocess Operations (CCBO) within Genentech's Pharma Technical Development (PTD) organization is seeking a highly experienced and self-motivated senior-level scientist to lead cell culture media development efforts for a diverse range of biological products.

The ideal candidate for this role will have extensive cell culture media development experience and demonstrated strengths in fostering teamwork and collaboration with an inclusive mindset.

The successful candidate will lead media development for mammalian cell lines expressing therapeutic antibodies, bispecific antibodies, complex biologics and other new modalities including gene and cell therapies. The successful candidate will provide scientific and strategic guidance to establish highly-productive next-generation platform processes in collaboration with multiple stakeholders within and outside CCBO/PTD. This position requires a passion for scientific rigor and excellent skills in leadership, communication, strategic thinking, decision making, influencing, and problem solving. The location for this role is our US Headquarters in South San Francisco, CA.

Responsibilities

• Develop chemically-defined cell culture media to meet different needs, including high-density cultures for biologics manufacturing, and cell-based therapies.

• Innovate, define strategies, and apply advanced technologies to improve cell culture performance and establish next-generation platform processes.

• Serve as primary in-house expert for state-of-the-art practice in media development.

• Provide technical leadership and strategic guidance to support technical/product teams, media preparation operations, raw material assessments, and supply chain updates.

• Guide, motivate, and develop staff in the Media and Process Group (MPG) within CCBO, with emphasis on defining their technical priorities and focus.

• Cultivate a lean mindset with focus on simplification and continuous improvement.

• Interface effectively within CCBO department and PTD, as well as with other internal Genentech/Roche organizations and external collaborators.

• Anticipate, identify, and resolve issues, with escalation and stakeholder communication where appropriate.

• Exert influence inside and outside the company through presentations, publications, and participation in meetings.

The successful candidate will have an established track record for strong technical leadership in cell culture media development. Other requirements for this role include:

• PhD (biological sciences, chemical engineering or related discipline) with 10+ years of relevant work experience OR BS/MS (biological sciences, chemical engineering or related discipline) with 14+ years of relevant work experience.

• Solid understanding of cell metabolism and tools for metabolic pathway analyses.

• Expertise in using computational methods, metabolic models, statistical design of experiments, -omics, and other current technologies to improve cell culture processes.

• Prior experience in media development for mammalian cell cultures.

• Prior experience in technology transfer and development of cell-based therapies is a plus.

• Demonstrated ability to lead and drive technical projects to completion through scientific rigor and strong organization skills.

• Proven track record of managing and developing highly productive technical teams with an inclusive mindset.

• Proven track record of building and maintaining strong relationships with partners, customers, and collaborators.

• Proven track record of excellent verbal and written communication through conference presentations and publications.

This is an onsite position based out of South San Francisco, California, USA.

Relocation benefits are available for this position.

The expected salary range for this position based on the primary location of South San Francisco, CA is $180,700 to $335,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.