Mass Spectrometry Sr. Research Scientist

Job Description

General Summary:

We are seeking a Mass Spectrometrist to join the Chemical Biology group in Vertex Pharmaceuticals. The ideal candidate is a motivated, detail orientated, life-long learner with strong technical expertise in mass spectrometry, chemical biology, and analytical biology. The successful candidate will creatively use their skills to answer a broad range of scientific challenges and questions in small molecule discovery and elucidation of biological mechanisms. This team member will have the opportunity to participate in a highly collaborative, multi-disciplinary, and fast-paced research environment striving for transformative new therapies.

Key Duties and Responsibilities:

• Execute a wide range of cellular and biochemical approaches to enrich, deplete, label, extract, and prepare analytes for mass spectrometry. This includes proteomic, chemoproteomic, lipid, and small molecule workflows.
• Design and execution of studies interrogating protein-protein interactions, chemo-proteomics, signaling, and homeostasis at the proteome-wide scale using DIA, PASEF, and DDA methods.
• Create high throughput PRM assays for classically difficult to measure analytes to enable target discovery, hit validation, biomarker and mechanism of action studies. This may include PTMs, non-genomic sequences, lipids, and low abundance peptides and small molecules.
• Create data analysis workflows for rapid interpretation, visualization, reporting and QC of mass spectrometry data.
• Maintain and troubleshoot LC-MS equipment, specifically, Thermo and Bruker systems.
• Teamwork in a multi-disciplinary matrixed environment, collaborating on shared scientific questions. Proactively communicating ideas, plans, and results.

Knowledge and Skills:

• Deep technical knowledge and experience to independently generate, optimize, execute, and troubleshoot LC-MS methods for a wide variety of experimental paradigms and instrumentation.
• Demonstrated understanding of quantitative rigor regarding instrument performance, assay figures of merit, and statistical analyses.
• Experience with quantitative analysis of mass spectrometry software such as: Spectronaut, Skyline, Proteome Discoverer, and MsFragger
• Basic molecular biology skills and experience; cell culture, immunoprecipitation, protein assays, etc
• The ability to communicate ideas and updates clearly and concisely across various audience levels. Articulate in cell and molecular biology, analytical quantification, and drug discovery concepts.

Education and Experience:

• Ph.D. in life sciences with 3-5 years hands-on experience in 'omics mass spectrometry and biology. Candidates with an MSc with 5+ years or BS with 8+ years of relevant experience will also be considered.

Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com