Postdoctoral Fellow - Cell Culture and Bioprocess Operations, Park Lab

A Postdoctoral Fellow position is available for a highly motivated and independent candidate to join the laboratory of Dr. Jonathan Park in the Research Materials Group (RMG) within the Cell Culture and Bioprocess Operations (CCBO) department at Genentech. RMG supports Research & Development efforts across the company by performing transient transfections to produce recombinant proteins.

This position will focus on developing a novel, high-titer Chinese Hamster Ovary (CHO) transient expression platform. The project aims to understand and overcome the biological bottlenecks of transient gene expression (TGE) in CHO cells, such as limiting factors like nuclear DNA uptake, cell cycle progression, and transcriptional activity, which restrict current protein yields.

You will utilize advanced molecular and genetic engineering approaches, including OMICS, CRISPR/Cas9, and other advanced molecular biology tools, to identify and overcome intracellular barriers to plasmid delivery and expression. You will explore ways to improve protein expression, including screening genome-wide libraries for increased expression, with the ultimate goal of optimizing a cell line for a high-throughput transient transfection process.

The Opportunity:

• You will have opportunities to productively collaborate with other researchers across gRED (Genentech Research and Early Development) and PTD (Pharmaceutical Technical Development), present your work to project teams, and contribute to scientific publications.

• As a member of the RMG and CCBO, you will gain exposure to the pipeline from early Drug Discovery to Development, contributing to the reduction of cycle times for lead molecule identification.

• You will be part of the Genentech post-doctoral training program that provides an outstanding environment and the opportunity to pursue fundamental basic science questions in an environment focused on drug development and breakthrough discoveries.

Who You Are:

• Ph.D. with a proven track record of excellence in Chemical Engineering, Bioengineering, Molecular Biology, Cell Biology, or a related field.

• Must have advanced at least one key research project as evidenced by a first-author paper published or accepted in a leading peer-reviewed journal.

• Independent scientist with outstanding communication skills, a strong passion and commitment to science and bioprocess innovation, who works well within a team.

• Excited about applying genetic and molecular engineering to solve complex challenges in protein production.

Preferred Qualifications:

• Hands-on experience with mammalian cell culture (specifically CHO cells) and transient expression systems is highly desired.

• Experience with molecular biology techniques, including vector design, cloning, and genetic engineering (e.g., CRISPR/Cas9, transposon-mediated systems).

• Working knowledge of transfection methods or engineered transcription/translation systems is a plus.

• Familiarity with high-throughput screening or automated liquid handling systems is advantageous.

The expected salary range for this position based on the primary location of South San Francisco California is $100,000 to $106,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Relocation benefits are available for this job posting.

Postdoc Program

Elevate your research career to new heights with Genetech's Postdoctoral Program! Join a prestigious community of early career scientists and kick-start your journey toward becoming a scientific leader in biotechnology and bioengineering. With competitive salaries and fully funded research expenses, you can dedicate yourself to groundbreaking research that aligns with Genentech strategic ambitions.

The postdoc program is designed to empower recent Ph.D. graduates to conduct world-class research, publish in top-tier journals, and build a robust scientific network. By joining us, you will receive the mentorship and support necessary to develop into an independent scientist and leader.

The Genentech Postdoc Program provides access to world-class seminars, professional development workshops, and networking opportunities. Apply now to Genentech Postdoctoral Program and unlock your full potential!

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