Post Doctoral Fellow

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Postdoctoral Research Associate - Structural Biology & CryoEM

Antony Laboratory of Structural Enzymology, Department of Biochemistry & Molecular Biology, Saint Louis University School of Medicine

The Antony Laboratory is seeking multiple highly motivated Postdoctoral Research Associatesto join a dynamic, interdisciplinary team investigating the molecular and structural mechanisms of enzymes involved in DNA repair, recombination, mRNA processing, and longrange electron transfer. Our lab applies advanced structural and biophysical methodologies including cryoelectron microscopy (cryoEM), Xray crystallography, singlemolecule fluorescence, and enzyme kinetics to elucidate how large macromolecular assemblies carry out essential biological processes.These positions are supported by NIH (NIGMS/NCI)and DOEfunding and offer the opportunity to work on highimpact structural biology problems with broad relevance to genome maintenance and energy transduction.

Research Areas

Postdoctoral researchers will lead structural and mechanistic studies on one or more of the following systems:

• Protein complexes involved in DNA repair and recombination, including mediators of homologous recombination and replication-associated DNA processing (NIH-funded).

• Nitrogenase and nitrogenaselike oxidoreductases, focusing on structure-function relationships and conformational dynamics involved in electron transfer (DOEfunded).

• Ribosomal and RNAprotein complexesrelevant to translational regulation and RNA recognition.

Primary Job Responsibilities

• Determine highresolution structuresof large enzyme complexes using cryoEM (single-particle reconstruction and/or cryoEM sample preparation and data collection).

• Perform protein purification, biochemical characterization, and reconstitutionof large multisubunit assemblies.

• Integrate structural data with biophysical, singlemolecule, and kineticapproaches to define mechanistic models of enzyme function.

• Design and execute independent research projects within the broader goals of the lab.

• Prepare manuscripts for publication and present research at national and international meetings.

• Mentor graduate and undergraduate trainees and contribute to a collaborative lab environment.

Required Qualifications

• A Ph.D. in Biochemistry, Structural Biology, Biophysics, Molecular Biology, or a related field.

• A strong publication recorddemonstrating expertise in structural biology.

• Handson experience in cryoEM, Xray crystallography, or advanced structural methods.

• Demonstrated ability to work effectively with large enzyme complexesor multi-protein assemblies (highly desirable).

• Strong communication, organizational, and problemsolving skills.

Preferred Expertise

Candidates with one or more of the following will be given priority:

• CryoEM grid optimization, data collection (Krios/Glacios), and reconstruction workflows

• Structural analysis of dynamic/heterogeneous complexes

• Electron transfer enzymes or redoxactive metalloproteins

• DNAprotein interaction studies, including DNA repair complexes

• Singlemolecule biophysics (smFRET or optical tweezers)

• Experience with FeS proteins or nitrogenaserelated systems

About the Antony Lab

Our lab explores how enzymes function at the molecular level by integrating structural biology (cryoEM and Xray), biophysics, and mechanistic enzymology. We dissect how enzymes recognize substrates, coordinate within large assemblies, and achieve high fidelity during DNA repair, recombination, and electron transfer. We are located within the Edward A. Doisy Department of Biochemistry & Molecular Biologyat Saint Louis University, a collaborative research environment with cuttingedge instrumentation and strong institutional support.

The Antony Lab is deeply committed to supporting the career development of postdoctoral scholars and preparing them for successful independent research careers. Postdocs are provided with protected time specifically dedicated to crafting competitive K99/R00 Pathway to Independence proposals, along with structured mentoring to refine research aims, identify training needs, and build a compelling scientific narrative. In addition to leading high-impact projects within the lab's funded research programs, trainees are encouraged to develop independent project directions that can form the foundation of their future laboratories. Our mentoring philosophy emphasizes scientific independence, strategic career planning, grant-writing skills, and visibility within the research community, ensuring each postdoctoral researcher is well-positioned for a smooth transition to the next stage of their career.

Function

Scheduled Weekly Hours:

Saint Louis University is an equal opportunity/affirmative action employer. All qualified candidates will receive consideration for the position applied for without regard to race, color, religion, sex, age, national origin, disability, marital status, sexual orientation, military/veteran status, gender identity, or other non-merit factors. If accommodations are needed for completing the application and/or with the interviewing process, please contact Human Resources at 314-977-5847.