Principal/Sr Principal Scientist - Applied Genetics

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.
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Position Summary

We are seeking a talented and motivated individual to join our team as a Principal Scientist/Senior Principal Scientist in Applied Genetics within the R&D Translational Sciences team. The R&D Translational Sciences group generates and applies human genetics, genomics, and biomarker insights into key GSK disease areas and product strategies. The successful candidate will have experience in human genetics, statistical genetics, genetic epidemiology, or a related discipline with high computational skills, and will be excited to apply their expertise in human genetics to the development of new medicines. The Principal Scientist/Senior Principal Scientist will be responsible for performing human genetics & statistical genetics analyses in key disease areas, evaluating genetic evidence and causal biology in support of therapeutic target hypotheses, evaluating and implementing of new analytical methods, and effectively communicating their results and interpretation to peers and leaders. They will have experience working in multi-disciplinary teams to answer complex scientific questions.

This role will provide YOU the opportunity to lead key activities to progress YOUR career.

Key Responsibilities

In this role, you will:

• Apply expertise in human genetics, statistical genetics, genetic epidemiology, or a related discipline to support the development of new medicines.
• Contribute to the ongoing development and iteration of scaled and automated genetic assessment tools to support the advancing science of drug target identification and validation.
• Develop and/or critically evaluate new methods to derive and apply genetic insights to support the development of therapeutic target hypotheses.
• Perform and apply at-scale and bespoke computational and statistical analyses (e.g., GWAS, WGS, Mendelian Randomization, rare variant association testing, and variant to gene mapping) and implement new analytical methods to infer molecular mechanisms to elucidate and interrogate therapeutic hypotheses
• Evaluate genetic and causal biology evidence to support therapeutic target hypotheses and provide clear and concise communication of results and interpretation to peers and leaders.
• Collaborate effectively in multi-disciplinary teams (internal and external) to answer complex scientific questions.
• Identify and implement creative solutions to address challenging scientific questions.

Basic Qualifications

• Ph.D in human genetics, statistical genetics, genetic epidemiology, or related disciplines with strong computational and quantitative focus.
• Experience in development, critical evaluation and application of analyses methods to answer complex scientific questions
• Experience in performing analyses and the interpretation of findings of large-scale population based genetic studies (e.g., GWAS and WES/WGS approaches, MR and variant to gene mapping)
• Experience evaluating and integrating genetic and genomic data to evaluate strength of causal genetic evidence (e.g., QTL mapping & integration, causal inference, pathway enrichment)
• Proficient in programming/scripting in R or Python and working within cloud-based computing platforms (e.g., AWS and/or Google Cloud)
• Experience in working with genetics databases and resources including key biobanks and disease-specific consortia data sources

Preferred Qualifications

• Experience working in multi-disciplinary teams to answer scientific questions and influence scientific plans/project decisions.
• Excellent communication skills to effectively convey complex scientific concepts to peers and leaders
• Proactive and innovative mindset with the ability to identify and implement creative solutions and demonstrated strong problem-solving skills
• Ability to work flexibly and adapt to changing priorities and timelines.
• Passion for advancing the science of drug target identification and validation.
• Experience in software development, both independently and as part of a team, developing well-documented solutions that other scientists can use, understand and debug. Strong understanding and experience with implementation of FAIR data principles.

Work model

This role is based in the United States and follows a hybrid working model under GSK's Performance with Choice approach. You will balance on-site collaboration with focused remote work.

How to apply
If this role matches your skills and purpose, we want to hear from you. Please apply with your CV and a short message describing how your experience maps to the role and the impact you want to make. We welcome applicants from all backgrounds and encourage people who value inclusion, teamwork and learning to apply.

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Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at HR.AmericasSC-CS@gsk.com where you can also request a call.

Please note should your inquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the link where you will find answers to multiple questions we receive

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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