Scientist, Oligo Discovery Biology (Sequencing Assays)

Business Introduction

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.
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Our approach to R&D

Position Summary

GSK is seeking a highly motivated Scientist to join the growing Oligo Discovery Biology group. In this new role, you will be pivotal in driving the team's sequencing strategy, responsible for developing and executing next-generation sequencing (NGS) workflows to measure the efficacy and specificity of GSK's diverse oligonucleotide modalities (ASOs, siRNAs, SSOs & RNA editors). Your work will be critical in supporting the platform's high-throughput screening efforts and advancing our therapeutic programs.

Responsibilities

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Design, optimize, and execute next-generation sequencing (NGS) assays (e.g., RNA-seq, Amp-Seq) to characterize oligonucleotide activity, including on-target efficacy and transcriptome-wide off-target effects.

• Independently manage the wet-lab workflow from nucleic acid extraction (RNA/DNA) through to NGS library preparation and quality control.

• Perform primary analysis of sequencing data for quality assessment and collaborate with bioinformatics colleagues on the interpretation of complex datasets.

• Analyze and interpret experimental results, clearly communicating findings and their impact to the project team and stakeholders.

• Collaborate effectively with team members and cross-functional partners in biology, chemistry, and bioinformatics to advance platform capabilities and portfolio projects.

• Maintain meticulous records of experiments, sample metadata, and results in an electronic laboratory notebook (ELN).

Why You?

Basic Qualifications
We are seeking professionals with the following required skills and qualifications to help us achieve our goals:

• MS with 3+ years, or BS with 5+ years, in molecular biology, cell biology, biochemistry, or a related field.

• 2+ years of experience with next-generation sequencing.

• Experience with independently planning and executing experiments and analyzing and interpreting results

• Experience with next-generation sequencing (NGS) workflows, specifically including library preparation for bulk RNA-seq.

• Experience with core molecular biology techniques, including DNA/RNA extraction, quantification, and quality control.

• Experience with quantitative PCR methods such as RT-qPCR and/or digital PCR (dPCR).

• Experience with laboratory automation and liquid handlers (e.g., Tecan, Echo, Viaflo) for high-throughput sample processing.

• Experience in drug discovery and/or high throughput screening, particularly with oligonucleotide therapeutics.

Preferred Qualifications
If you have the following characteristics, it would be a plus:

• Previous experience in biotech or pharmaceutical research environments.

• Basic experience with command-line environments (Linux/Unix) for preliminary data quality control and analysis is a significant plus.

• Experience with mammalian cell culture and transfection techniques.

• Experience with advanced sequencing applications such as single-cell RNA-seq (scRNA-seq), spatial transcriptomics, or long-read sequencing (PacBio, Oxford Nanopore).

• Strong written and verbal communication skills and experience keeping clear laboratory records.

• Sense of urgency, flexibility, independence and accountability

• Ability to communicate both verbally and in writing with all levels both inside and outside of organization.

• Maintain a high level of integrity while balancing multiple priorities and responsibilities.

• Must be a committed team player prepared to work in and embrace a team-based culture.

• Strong attention to detail with the ability to independently design experiments, troubleshoot technical issues, and analyze results.

#GSK-LI

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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