Postdoctoral Fellow
 McLean Hospital | |
 United States, Massachusetts, Belmont | |
| 115 Mill Street (Show on map) | |
 Apr 08, 2026 | |
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Postdoctoral Fellow - T-Regulatory Cells and Cell Replacement Therapy
We are seeking a highly motivated Postdoctoral Fellow to join our research program focused on the role of regulatory T cells (Tregs) in improving outcomes in cell replacement therapy for neurodegenerative disease. The successful candidate will lead studies aimed at defining how Tregs modulate immune responses associated with transplantation and how they may enhance graft survival and function. The postdoctoral fellow will investigate the immunosuppressive activity of Tregs, including their capacity to regulate host inflammatory responses before and after transplantation. A major emphasis of the project will be to understand the mechanisms that influence Treg survival, persistence, and function post-transplantation. The fellow will also study approaches to mitigate the pro-inflammatory response associated with needle trauma, a key barrier to successful cell delivery and engraftment. In addition, the candidate will explore the biology of local brain-resident or tissue-localized Tregs and their role in limiting neuroinflammation within the transplant microenvironment. This work will integrate cellular immunology, transplantation biology, and neuroinflammation, with the goal of developing strategies that improve the safety and efficacy of regenerative therapies in the central nervous system. The ideal candidate should have a strong background in immunology, neuroimmunology, stem cell biology, transplantation biology, or a related biomedical field. Experience with T-cell biology, flow cytometry, in vitro immune assays, animal models, histology, and molecular or cellular techniques will be highly desirable. Candidates should be independent, scientifically rigorous, and enthusiastic about working in an interdisciplinary and translational research environment. This position offers the opportunity to contribute to a growing area of investigation at the interface of immunology, neuroscience, and regenerative medicine, with strong potential for high-impact publications and translational relevance. Position Summary The Postdoctoral Fellow will lead research efforts aimed at defining the role of regulatory T cells in cell replacement therapy, with particular emphasis on transplantation-associated inflammation and graft protection. Research activities will include evaluating the immunosuppressive properties of Tregs, determining their survival and persistence following transplantation, and identifying mechanisms to reduce the pro-inflammatory response associated with needle trauma during cell delivery. The fellow will also investigate the role of local Tregs in the brain and their contribution to the control of local inflammation within the transplant environment. Default Add'l Job Description The McLean Hospital Corporation is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. | |