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Research Technician - Scanziani Lab

Howard Hughes Medical Institute (HHMI)
United States, California, San Francisco
June 23, 2022

Primary Work Address: 1550 4th Street, Suite 190, San Francisco, CA, 94158-0724

Current HHMI Employees, click here to apply via your Workday account.

Howard Hughes Medical Institute (HHMI) is an independent, ever-evolving philanthropy that supports basic biomedical scientists and educators with the potential for transformative impact. We make long-term investments in people, not just projects, because we believe in the power of individuals to make breakthroughs over time. HHMI scientists have radically advanced the understanding of cells, the brain, the immune system, the development of organs, and how to treat many diseases. Founded in 1953 by aviator and industrialist Howard R. Hughes, HHMI is headquartered in Chevy Chase, Maryland, and employs more than 2,500 people across the U.S.

At HHMI, you are not just an employee - you are a part of a creative and talented team with colleagues whose expertise ranges from biomedical research to investment management, from information technology to law. We encourage collaborative and results-driven working styles and offer an adaptable environment where employees can do their best work. As HHMI scientists continue to push boundaries in laboratories and classrooms, you can be sure that your contributions while working at HHMI are making a difference.

We are currently looking for a proactive, detail-oriented Research Technician to work in the lab of Dr. Massimo Scanziani at the University of California, San Francisco. The Scanziani lab works to understand the mechanisms by which elementary circuits of neurons control the spatial and temporal structure of cortical activity. Towards this goal, they use in vivo and in vitro electrophysiological, imaging, and anatomical techniques as well as behavioral approaches. Their model system is the rodent's sensory cortex. Their work is revealing the logic and the mechanisms by which elementary circuits, the building blocks of cortical architecture, orchestrate cortical activity. More information about the Scanziani lab can be found by visiting https://www.scanzianilab.org/index.html

The ideal candidate is a professional, collegial individual who will enjoy working with mice, can work well independently and as part of a larger team, and is looking to grow professionally while supporting multiple projects in a medium-sized collaborative academic laboratory. The chosen candidate will be responsible for genotyping, handling, and breeding necessary to maintain the Scanziani lab's colony of mice and provide them for various experiments in the lab along with histology, IF staining, and performing small surgeries and brain dissections. This is an excellent opportunity for a recent college graduate who would like to gain a couple more years of academic research experience before applying to graduate school.

Principal Responsibilities:

* Perform regular checks of every cage in the mouse colony to monitor health and presence of new litters.

* Address any necessary health issues with the colony and take appropriate action in a timely manner.

* Establish new breeding pairs of mice to fulfill experimental needs of the laboratory.

* Read and adhere to all relevant protocols, assist with drafting animal protocol amendments and renewals, and ensure mouse health and safety by adhering to all regulatory bodies' standards for mouse maintenance.

* Perform PCR reactions.

* Prepare slides (vibratome and cryostat) and antibody staining

* Perform small surgeries and brain dissections on mice.



* A bachelor's degree in biology or a closely related discipline is required.


* Previous hands-on academic laboratory experience along with a solid understanding of molecular biology techniques (PCR, genotyping, etc.) is strongly preferred. Significant laboratory experience obtained during undergraduate studies is acceptable and will be considered.

* Previous experience with handling mice would be a plus.

* Previous experience with immunofluorescent staining would be a plus. Knowledge, Skills, and Abilities

* Superior verbal and written communication skills.

* Superior organizational skills with meticulous attention to detail.

* Superior prioritization skills and time management skills.

* Strong sense of initiative, self-motivation, and capacity for creative problem solving.

* Proficient computer skills (comfort with PC or Mac, Microsoft Office Suite, etc.).

* Ability and willingness to learn new techniques and skills.

* Comfort and willingness to handle and work regularly with live mice.

* Ability to interact positively with all levels of staff.

* Ability to work efficiently and be adaptable to changing priorities

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances.

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job's principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word "may," the Essential Duties and Responsibilities described above are "essential functions" of the job, as defined by the Americans with Disabilities Act.

Compensation and Benefits

Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our site to learn more.

HHMI is an Equal Opportunity Employer

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