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Postdoctoral Associate - Lefkowitz Lab

Howard Hughes Medical Institute (HHMI)
United States, North Carolina, Durham
April 08, 2023
Primary Work Address: MSRB 1, Suite 301, Research Drive, Durham, NC, 27710 Current HHMI Employees, click here to apply via your Workday account.

The Lefkowitz lab is currently seeking an innovative, inventive, and determined Postdoctoral Associate. The Lefkowitz lab has a longstanding interest on the elucidation of the molecular properties and regulatory mechanisms controlling the function of G protein-coupled receptors. As model systems we utilize the so-called adrenergic receptors for adrenaline and related molecules. The goal is to learn the general principles of signal transduction from the outside to the inside of the cell which are involved in systems as diverse as sensory perception, neuro- transmitter and hormonal signaling. Studies are performed with isolated protein, whole cells in culture and even in vivo in whole animals.

Successful candidates need to have a strong knowledge of structural biology. Candidate must be able to work independently, as well as, in a collaborative group environment. Candidate should have effective communication skills, is self-motivated and has a strong work ethic.

What we provide:
  • A competitive compensation package, with comprehensive health and welfare benefits.
  • A flexible schedule
  • One on one mentorship relationship
  • Associate Supplement:Annual supplement for eligible postdoctoral Associates to spend on health care, retirement, childcare, or other personal use.
What you'll do:
  • Performs research and/or development in collaboration with others for projects.
  • Makes detailed observations, analyzes data, and interprets results.
  • Exercises technical discretion in the design, execution, and interpretation of experiments that contribute to project strategies.
  • Prepares technical reports, summaries, protocols, and quantitative analyses.
  • Maintains familiarity with current scientific literature.
  • Contributes to project process within their scientific discipline.
  • Investigates, creates, and develops new methods and technologies for project advancement.
  • Maintains high level of professional expertise through familiarity with scientific literature.
  • May participate in scientific conferences and contribute to scientific journals.
  • Uses professional concepts in accordance with HHMI's objectives to solve complex problems in creative and effective ways.
  • May determine methods and procedures on new assignments and may provide guidance to staff in the laboratory.

In addition to the duties specifically identified by this job description, the position will include other duties if and as assigned by the direct supervisor or others with supervisory authority over this position.

What you bring:
  • Ph.D. degree in a related field of study
  • Up to five years of experience working in a scientific laboratory.
  • Strong operational knowledge of advanced lab equipment
  • Required experience with X-Ray Crystallography or Cryo-Electron Microscopy
  • Ability to provide work and supervise directions to others
  • Ability to work successfully within a collaborative and collegial environment and develop this ability in others.
  • Ability to review goals, analyze processes necessary to achieve those goals, and develop techniques and systems required to meet those goals. Often explores new areas and seeks opportunities to apply new knowledge to work.

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet).

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job's principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word "may," the Essential Duties and Responsibilities described above are "essential functions" of the job, as defined by the Americans with Disabilities Act.

Compensation and Benefits

Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our site to learn more.

Compensation Range

$70,000.00 (minimum) - $80,500.00 (midpoint) - $91,000.00 (maximum)

Pay Type:


HHMI's salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal equity when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range.