Director, Next Wave Research (Medical Geneticist)

This role is considered On-Site.

Summary

The Director Next Wave is an MD position within the Research organization. Primary responsibilities include leading efforts within the biology team to identify indications/unmet need for a portfolio of preclinical targets as well as playing a role in the identification of new targets to enter the pipeline. Alnylam has extensive access to large genotype-phenotype datasets (e.g., UK biobank and Our Future Health) and rely heavily on human genetic data to discover and validate our drug targets. It is expected that the successful candidate will be comfortable working with the statistical genetics team to apply this strategy. The current Alnylam portfolio is therapeutic area agnostic, and currently spans cardiometabolic, neurological, orphan, renal, and ocular diseases with plans to expand into numerous other indications and tissues.

A key part of this role will involve outreach to external experts to gain input which will be used to prioritize our targets and help generate ideas for pragmatic clinical development paths. Furthermore, the successful candidate will also work closely with colleagues in clinical development to create initial clinical development plans with the aim of expediting filing of CTAs/INDs with the strongest basis for proof of concept in Phase 1.

Major Responsibilities:

• Identify targets/indications where Alnylam technology can deliver transformative medicines.
• Lead cross-functional teams to identify and prioritize indications for targets within Research.
• Drive external interactions with key opinion leaders to develop indication and early clinical strategy and identify targets and diseases of interest.
• Help make prioritization decisions around the internal early-stage portfolio.
• Actively participate in target discovery efforts including working closely with the statistical genetics and biology teams.

Qualifications:

• MD or MD/PhD with Board certification in medical genetics and genomics or specialty preferred.
• 4 years of clinical experience.
• Proven track record in evaluation, diagnosis, management and treatment of inherited conditions in patients across all ages from birth to adulthood.
• Experience in bench/lab work and a strong track record of publications.
• Inquisitive, discovery mindset with interest in early clinical development and discovery research.
• Inter-personal skills with a highly collaborative approach to achieving goals critical.
• Excellent communication and presentation skills are necessary to represent team efforts at key internal governance meetings, including a world-class SAB (https://www.alnylam.com/our-science/alnylam-scientific-advisory-board), and externally in various scientific and other forums.

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.