Scientist, Protein Sciences

This role is considered On-Site.

Overview

We are seeking a Scientist to join our Protein Sciences group within Medicinal Chemistry to help with antibody engineering, production, conjugation and development efforts. The candidate must be independent, goal oriented, technically competent, and able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with scientific background in protein expression, purification, protein conjugation and analytical techniques, who are comfortable working in a fast-paced entrepreneurial environment.The successful candidate will have a strong background in antibody engineering with conjugation experience being a plus.

This position is onsite and will be located at 675 W. Kendall St. Cambridge, MA 02142

This is a laboratory-based position

Key Responsibilities

• Design of antibodies sequences from literature and patent sources (bispecifics, Fc fusions, Fabs, scFvs)
• Understanding of antibody ligand/target interactions (HDX and crystallography experience is nice to have)
• Work closely with a team of scientists to help deliver and validate antibodies (Fabs, Fc fusions, bispecifics) at various scales of production
• Characterize proteins using several methods (SDS-PAGE, melting point, size-exclusion chromatography, ionic-exchange, UV-Vis, DLS, ELISA)
• Validate proteins using BLI (Octet) or SPR (Biacore) and report kinetics
• Contribution to group organization, productivity, and expertise through collaboration and idea exchange
• Meet quality, quantity, and timelines in all assigned projects
• Support the discovery efforts in protein sciences
• Proper electronic notebook record keeping
• Communication of experimental plans and data to multiple cross-functional scientific teams
• Will be part of cross-functional teams including biologists, chemists, and pharmacologists to contribute to the strategic direction of research programs across multiple therapeutic modalities

Qualifications

• The candidate should have a PhD degree with 0-2 year of post-doctoral experience in biology, biochemistry, biophysics, chemistry, or a related field with relevant laboratory experience
• Experience with antibody design and purification (including bispecifics, Fc fusions, Fabs, scfvs)
• Experience with antibody-drug conjugates is nice to have
• Pharmaceutical or biotechnology industry experience is preferred
• Experience with transient protein expression in mammalian cells
• Experience with AKTA and unicorn software
• Experience with sterile cell culture techniques
• Experience with recombinant protein analysis (affinity, size exclusion, reverse phase, hydrophobic interaction, ion exchange chromatography, SDS-PAGE, and UV-VIS spectroscopy)
• Experience with the chemical conjugation of proteins
• Experience with SPR and/or Octet binding experiments
• Passionate about driving his or her projects from the bench to independently contribute to research directions and solve challenging issues
• Detail oriented, self-motivated, and comfortable working with highly technical projects
• Ability to work on multiple projects simultaneously and deliver conclusive results
• Highly adaptable and responsive to new priorities in a fast passed environment
• Effective written and oral communication skills
• Experience preparing and presenting using Powerpoint software
• Team oriented with strong work ethic

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.