Scientist, DMPK

This role is considered On-Site.

Overview

Join our innovative research and development (ReDev) team, dedicated to advancing oligonucleotide-based therapeutics. We are seeking a highly skilled Ph.D. scientist with expertise in drug disposition mechanisms and pharmacokinetic/pharmacodynamic (PK/PD) relationships. As a key representative of the DMPK function, you will collaborate with cross-functional teams to propel novel therapeutics into clinical development.

Key Responsibilities

* Design and execute in vitro and in vivo drug metabolism, disposition, and pharmacokinetics studies to characterize and optimize the pharmacokinetic and metabolic properties of oligonucleotide-based therapueticcandidates.

• Apply quantitative analysis and mathematical modeling to integrate literature and competitor data on pharmacokinetics, pharmacodynamics, pharmacology, safety, and efficacy. Use this integrated data to evaluate and optimize the developability of therapeutic candidates.
• Draft and review PK, PK/PD, and toxicokinetic (TK) study reports, as well as nonclinical sections of Investigational Brochure (IB), to support regulatory submission for early clinical development.
• Represent the DMPK function on interdisciplinary project teams, collaborating with Research, Toxicology, Bioanalysis, and Clinical Pharmacology groups to ensure high-quality, data-driven nonclinical-to-clinical translation and contribute to shaping clinical development strategies.

Qualifications

• Educational Background: Ph.D. in Pharmacokinetics, Pharmacology, Biophysics, Bioengineering, or a related field.
• Expertise: 0-2 years of experience in the biotech or pharmaceutical industry, with a strong understanding of PK and PK/PD principles. Proficiency in model-based data integration, analysis, and projection.
• Passion for Drug Discovery: Demonstrated innovative and critical thinking skills in disease mechanisms and drug discovery processes, with a proven ability to solve complex problems through hypothesis-driven study design and investigation.
• Communication and Teamwork: Strong interpersonal, written, and verbal communication skills, with a demonstrated ability to collaborate effectively in a team environment.

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.