Senior Associate Scientist, Molecular Histologist

This role is considered On-Site.

Overview

The Pathology team is seeking a Senior Associate Scientist, Molecular Histologist. Experience performing and evaluating immunohistochemistry and/or in situ hybridization is essential. Interpretation of labeled specimens requires an understanding of anatomy and histology and an ability to identify specific cell populations in tissue sections. Quantitative morphometrics and/or AI-assisted image analysis will be a component of the role. Multiple imaging modalities will be employed including chromogenic and multiplex fluorescence microscopy, spatial-seq, and when applicable confocal and electron microscopy.

Key Responsibilities

• Antibody optimization for immunohistochemistry
• Performs immunohistochemical and in-situ hybridization procedures
• Analyzes and evaluates assays for sensitivity and specificity
• Mounts, labels and distributes or scans prepared microscope slides to pathologists or to appropriate areas for interpretation
• Quantitative morphometrics and/or AI-assisted image analysis will be a component of the role. Multiple imaging modalities will be employed including chromogenic and multiplex fluorescence microscopy, spatial-seq, and when applicable confocal and electron microscopy.
• Responsible for maintaining reagents, preventative maintenance procedures and troubleshooting for relevant equipment
• Proficiency in tissue trimming/embedding and microtome/cryostat tissue sectioning
• Maintain regulatory compliance and SOPs
• Cross-functional collaboration with the research group and broadly with other departments throughout the company

Some workday hours flexibility depended on study needs

Qualifications

• Minimum Qualifications:
  • BS in life sciences with 5+ years of relevant laboratory experience or Masters degree with 3+ years of relevant laboratory experience.

• Essential skills:
  • Demonstrated ability performing IHC and/or ISH.
  • Experience performing AI-assisted image analysis and quantitative morphometrics (ie HALO etc)

• Desirable skills:
  • Experience in biotechnology or CRO-based pathology laboratory setting
  • Experience with Ventana, Leica or other automated immunostainers
  • Experience with ACD RNAscope
  • Experience with data entry
  • Experience with Image capture and Image Analysis (HALO etc)
  • Experience collecting and reporting laboratory metrics
  • Solid report writing skills

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.