Senior Scientist, Process Development

This role is considered On-Site.

Overview

Senior Scientist, Process Development will be responsible for leading drug substance process development projects for early-stage programs, with a focus on optimizing oligonucleotide process and developing process for oligonucleotides with novel chemical modifications. The role involves overseeing development projects, supporting nGMP drug substance manufacturing, and collaborating with various cross-functional teams within the organization. The ideal candidate must have strong problem-solving skills, extensive knowledge of oligonucleotide chemistry, and proven experience in oligonucleotide process development.

This position is onsite and will be primarily located at our Cambridge, MA location.

Key Responsibilities

• Leading or being actively involved in process development projects including oligonucleotide synthesis activities, process development, optimization and scale-up.
• Working closely with process sciences and cross-functional teams within the organization.
• In-process analytical method development and utilization.
• Communicate relevant information and results to CMC development department as well as other key stakeholders throughout the organization.
• Creation, review, and usage of SOPs and batch records employed for the in-house non-GMP oligonucleotide manufacturing.
• Technical protocols and reports authoring and reviewing.

Qualifications

• PhD in Organic/Medicinal Chemistry, Chemical Engineering with 3+ years post degree experience, preferably in an industrial setting.
• Strong experience and knowledge in oligonucleotide synthesis, purification, and characterization.
• Hands-on experience in automated solid-phase DNA synthesizer, demonstrated strong operational execution and problem-solving skills.
• Experience in analytical techniques (pH, HPLC, LC-MS etc.), or related hands-on experience, is preferred.
• Ability to work within cross-functional teams and work as a team player. Ability to lead projects and demonstrate strong oral & written communication, and presentation skills.
• Strong experience in record-keeping and excellent laboratory documentation practice are required.
• Strong commitment to preserving a high laboratory and scientific standard; maintaining a safe, clean, and orderly laboratory work environment.

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.