Senior Scientist, DMPK

Join our dynamic research and development team dedicated to advancing oligonucleotide-based therapeutics. We are seeking a highly skilled Ph.D. scientist to focus on the disposition mechanisms and pharmacokinetic/pharmacodynamic (PK/PD) relationships of our drug candidates. As a key member of our DMPK team, you will work collaboratively with colleagues across Research and Development. The Senior Scientist will be a highly motivated individual who will utilize their knowledge in ADME concepts, pharmacokinetics, and pharmacodynamic principles to advance the discovery and preclinical development of Alnylam's therapeutic siRNA programs.

Key Responsibilities

• Develop DMPK Strategies:Formulate and implement DMPK strategies that align with our platform, program objectives, and overall company goals to support robust discovery pipelines and facilitate successful global drug registration.
• Collaborate on siRNA Delivery:Work closely with Research scientists and project leaders to optimize siRNA delivery to target tissues, and aid in drug candidate selection, characterization, and progression into development.
• Integrate PK/PD Data:Partner with Research, Toxicology, and Clinical Pharmacology teams to apply model-based approaches for integrating PK/PD and safety data to guide clinical development plans.
• Represent DMPK:Actively participate in interdisciplinary teams, representing DMPK expertise and contributing to collaborative projects.
• Support Regulatory Submissions:Ensure timely delivery of detailed reports and key sections of regulatory documents to support INDs, NDAs, and other global regulatory submissions.

• Educational Background:Ph.D. in Pharmacokinetics, Pharmacology, Biophysics, Bioengineering, or a related field with 3+ years of experience.
• Expertise:In-depth knowledge of pharmacokinetics and PK/PD principles. Experience in usingpharmacokinetic software is a plus.
• Passion for Discovery:Demonstrated enthusiasm for drug hunting and problem solving.
• Analytical Skills:Proficiency in model-based data integration, analysis, and projection.
• Problem-Solving:Proven ability to solve complex problems and use modeling and simulation for data integration. Ability to work independently with excellent organization skills that enable working within timelines is required.
• Communication:Excellent interpersonal, written, and verbal communication skills.
• Experience:Priorexperience in pharmaceutical industry and a team environment is preferred.