Senior Scientist, Delivery Sciences (Kidney)

We are seeking a Senior Scientist to join our Delivery Sciences team group to help with our kidney delivery efforts. The candidate must be independent, goal oriented, technically competent, and able to work efficiently across multiple projects as well as cross-functionally. We are searching for enthusiastic, innovative, and highly motivated individuals. The candidate must have a scientific background in kidney biology and physiology with demonstrated experience in designing and characterizing preclinical models of human disease as well as kidney in vitro models. This is a laboratory-based position located at Alnylam's Cambridge office.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Develop and characterize renal complex in-vitro systems for evaluating target engagement (healthy and diseased).
• Develop in vivo disease models to assess pharmacological efficacy and validate therapeutic hypotheses.
• Execute standard molecular biology techniques (RT-qPCR, ELISA, Western blots, etc.).
• Work cross-functionally with teams across the organization to contribute to the strategic direction of kidney programs through carful experimental design and execution.
• Proper electronic notebook record keeping with high attention to detail.
• Clear communication of experimental plans and data to multiple cross-functional scientific teams.

Qualifications

• PhD in Cell Biology, Molecular Biology, or related field with 3-5 years of relevant kidney experience in a biopharma or academic setting.
• Deep understanding of kidney biology, physiology and pathology.
• Extensive experience with advanced cell culture systems including stem cell culture, 3D cultures, or organoids.
• Strong background in molecular biology techniques, imaging, and data analysis are required.
• Experience with oligonucleotide-based therapeutics will be preferred.
• Detail oriented, self-motivated, and comfortable working with cross-functional teams.
• Ability to work on multiple projects simultaneously and deliver conclusive results.
• Highly adaptable and responsive to new priorities in a fast-paced environment.
• Effective written and oral communication skills.
• Experience with ELN recording keeping.
  
  

U.S. Pay Range

$127,300.00 - $179,500.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science,Alnylamhas delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values:fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.