Senior Director, Manufacturing, CMC & Supply Chain Technology

Overview:

Alnylam is seeking a strategic and pragmatic IT leader to serve as Sr. Director, Manufacturing, CMC & Supply Chain Technology. This role will own the end-to-end digital strategy, operations, and application lifecycle across Manufacturing, Chemistry, Manufacturing & Controls (CMC), and Supply Chain in the Technical Operations and Quality (TOQ) organization - driving innovation, compliance, and operational excellence to enable Alnylam to scale with discipline, agility, and impact.

Reporting directly to the VP of ReDev & TOQ Technology, this leader will oversee the reliability and operations of critical enterprise systems while advancing a multi-year digital transformation. As a recognized expert in manufacturing, CMC, and Supply Chain technologies, the Sr. Director will be accountable for both day-to-day operational excellence and long-term strategy. They will manage a growing IT team, partner with senior business leaders, and ensure digital capabilities scale with Alnylam's global growth.

This hybrid role is based in Cambridge, MA (3 days/week onsite) with regular engagement at both our Cambridge headquarters and Norton, MA manufacturing site.

Key Responsibilities:

• Shape and execute the digital vision: Define, deliver, and continuously evolve a pragmatic multi-year digital transformation roadmap for Manufacturing, CMC, and Supply Chain, aligned with TOQ and Alnylam's enterprise strategy.
• Ensure operational excellence: Own the operations, performance, and compliance of core enterprise platforms (e.g., MES, Electronic Batch Records, Process Analytical Technology, Empower, ERP), ensuring reliable, compliant, and efficient system support across sites.
• Own the application lifecycle: Drive accountability for the full lifecycle of digital applications - from strategy and design through deployment, sustainment, upgrades, continuous improvement, and retirement.
• Strengthen compliance foundation: Ensure all systems meet GxP, data integrity, and global regulatory standards, maintaining audit readiness and safeguarding uninterrupted supply of medicines.
• Serve as strategic partner and expert: Act as the primary technology thought partner and domain expert for Manufacturing, CMC, and Supply Chain leaders, aligning digital capabilities with business and scientific priorities.
• Build and lead a high-performing team: Inspire, develop, and scale a skilled IT organization that supports both transformation and operations, fostering innovation, accountability, and pragmatic problem-solving.
• Integrate enterprise capabilities: Collaborate across IT domains (Research, Development, Commercial, Data & AI, Infrastructure, Security) and with external partners to deliver cohesive, enterprise-grade digital solutions.

Qualifications:

Required:

• Bachelor's degree in Computer Science, Engineering (e.g., Chemical, Industrial, Biochemical, Bioprocess, Biotechnology, or Pharmaceutical), or a related field; equivalent industry experience considered.
• 15+ years of progressive IT leadership experience with significant exposure to pharmaceutical or biotech manufacturing, CMC, and supply chain.
• Proven track record managing operations and application lifecycles in regulated (GxP) environments.
• Deep expertise in core platforms supporting Manufacturing/CMC/Supply Chain (e.g., MES, EBR, PAT, Empower, and ERP) and integration with adjacent systems (e.g., LIMS, QMS).
• Strong strategic mindset with a pragmatic approach - balancing long-term vision with reliable delivery of measurable business outcomes.
• Demonstrated success building and leading cross-functional, global teams.
• Exceptional stakeholder management and influencing skills across executives, scientists, and operations leaders.

Preferred:

• Advanced degree in Computer Science, Engineering (e.g., Chemical, Industrial, Biochemical, Bioprocess, Biotechnology, or Pharmaceutical), or related discipline.
• Experience in biotech or pharmaceutical organizations undergoing scale-up or global expansion.
• Familiarity with emerging digital technologies (AI/ML, IoT, cloud-based manufacturing platforms).

U.S. Pay Range

$226,800.00 - $306,800.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.