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Manager, Internal Audit

Alnylam Pharmaceuticals
paid time off
675 West Kendall Street (Show on map)
Mar 18, 2026
Overview

Alnylam Pharmaceuticals is looking for an Internal Audit Manager to be a key contributing member of the Internal Audit function for one of Cambridge's most innovative, publicly traded biotech companies, focused on translating the science of siRNA into human therapies. Reporting to the Senior Director, Internal Audit, the ideal candidate will have a solid background in audit, strong communications skills, the ability to work collaboratively with team members and stakeholders, and an enthusiastic drive to be a trusted advisor and enhance risk management and internal control through thoughtful and robust assurance and advisory activities. The Internal Audit Manager will be part of high-performing audit team with great opportunities for growth.

This is ahybrid position and will primarily be based in Cambridge, MA.

Key Responsibilities

  • Support the execution of and lead financial, compliance, operational, and strategic internal audits, both domestic and abroad to effectively assess Alnylam's risk management and internal control environment.
  • Perform and oversee audit procedures, including planning, scoping, and fieldwork execution in line with quality standards and timelines.
  • May assist with certain aspects of Alnylam's SOX program, coordinating with our co-source partner who is responsible for SOX controls testing.
  • Apply a systematic and risk-focused approach to evaluate and improve the effectiveness and efficiency of processes, internal controls, risk management and governance processes.
  • Leverage AI, analytics and data-driven audit techniques in the execution of audit activities, including scoping, fieldwork and report generation.
  • Prepare insightful written reports and work collaboratively with other expertise areas and the business to align on audit observations and management action plans.
  • Build strong relationships with key stakeholders across the organization while promoting ethical awareness.
  • Maintain the highest standards of professionalism and independence in the execution of responsibilities.
  • Support the operation and evolution of the Internal Audit function to keep pace with Alnylam's growth and priorities.

Qualifications

  • Bachelor's degree in Accounting, Finance, or related field
  • CPA, CIA, or equivalent professional certification is required
  • A combined minimum of 5 years' relevant experience in audit and controls functions
  • Experience with auditing and advising on governance, risk and controls including a strong understanding of audit principles and methodology
  • Experience within the life sciences sector, or related fields preferred
  • Experience with SAP ERP, audit software, Generative AI applications (e.g., Microsoft Copilot) and data visualization tools (e.g., Microsoft Power BI, Tableau, Qlik Sense) preferred
  • Excellent project management skills with the ability to coordinate and manage multiple priorities
  • Willing to travel up to 20%, domestic and international

#LI-MH1 #LI-Hybrid

U.S. Pay Range

$120,700.00 - $163,300.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

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